ArticleBJOG : an international journal of obstetrics and gynaecology2012
The effects of low to moderate alcohol consumption and binge drinking in early pregnancy on executive function in 5-year-old children.
Article in BJOG : an international journal of obstetrics and gynaecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Trial
- Clinical Features of Typically Developing Children with and without Prenatal Alcohol Exposure.The Journal of pediatrics · 2025Article
- Maternal alcohol consumption during pregnancy and child development: Role of ADH1B and ALDH2 gene polymorphisms-The Yamanashi Adjunct Study of the Japan Environment and Children's Study.Alcohol, clinical & experimental research · 2025Article
- Parental factors predicting social deviance and psychological outcomes in offspring: Evidence from the Avon Longitudinal Study of Parents and Children (ALSPAC).Nordisk alkohol- & narkotikatidskrift : NAT · 2024Article
- Low to Moderate Prenatal Alcohol Exposure and Neurodevelopmental Outcomes: A Narrative Review and Methodological Considerations.Alcohol research : current reviews · 2023Review
- Dose-Related Reduction in Hippocampal Neuronal Populations in Fetal Alcohol Exposed Vervet Monkeys.Brain sciences · 2022Article
- Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.Drug and alcohol dependence · 2022Article
- Reducing the Prevalence of Alcohol-Exposed Pregnancies in the United States: A Simulation Modeling Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2022Article
- Impact of prenatal alcohol exposure on neurodevelopmental outcomes: a systematic review.Health psychology and behavioral medicine · 2022Review
- Attention Deficit Hyperactivity Disorder (ADHD) and Associated Factors Among First-Year Elementary School Students.Journal of multidisciplinary healthcare · 2021Article
- Associations Between Early Low-Level Tobacco Smoke Exposure and Executive Function at Age 8 Years.The Journal of pediatrics · 2020Article
- Childhood perfluoroalkyl substance exposure and executive function in children at 8 years.Environment international · 2018Article
- Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study.International journal of hygiene and environmental health · 2018Article
- Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function.Frontiers in immunology · 2018Review
- The Early Developmental Outcomes of Prenatal Alcohol Exposure: A Review.Frontiers in neurology · 2018Review
- Impact of Prenatal and Subsequent Adult Alcohol Exposure on Pro-Inflammatory Cytokine Expression in Brain Regions Necessary for Simple Recognition Memory.Brain sciences · 2017Article
- Pre-conception and prenatal alcohol exposure from mothers and fathers drinking and head circumference: results from the Norwegian Mother-Child Study (MoBa).Scientific reports · 2016Article
- Effects of Moderate Prenatal Alcohol Exposure during Early Gestation in Rats on Inflammation across the Maternal-Fetal-Immune Interface and Later-Life Immune Function in the Offspring.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- "Did you ever drink more?" A detailed description of pregnant women's drinking patterns.BMC public health · 2016Article
Corrections and comments
- Commented on by
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- Erratum issued
- Erratum issued
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo examine the effects of low to moderate maternal alcohol consumption and binge drinking in early pregnancy on children's executive functions at the age of 5 years.
designFollow-up study.
settingNeuropsychological testing in four Danish cities 2003-2008. Population A cohort of 1628 women and their children sampled from the Danish National Birth Cohort.
methodsParticipants were sampled based on maternal alcohol drinking patterns during early pregnancy. When the children were 5 years old, the parent and teacher forms of the Behaviour Rating Inventory of Executive Function (BRIEF) were completed by the mothers and a preschool teacher. Parental education, maternal IQ, prenatal maternal smoking, the child's age at testing, and the child's gender were considered core confounding factors. The full model also included maternal binge drinking or low to moderate alcohol consumption, maternal age, parity, maternal marital status, family home environment, postnatal parental smoking, pre-pregnancy maternal body mass index (BMI), and the health status of the child.
main outcome measuresThe BRIEF parent and teacher forms.
resultsAdjusted for all potential confounding factors, no statistically significant associations between maternal low to moderate average weekly consumption and BRIEF index scores were observed.In adjusted analyses, binge drinking in gestational week 9 or later was significantly associated with elevated Behavioural Regulation Index parent Scores (2.04, 95% CI 0.33–3.76), and with the risk of high scores on the Metacognitive Index assessed by the teacher (OR 2.06, 95% CI 1.01–4.23) [corrected].
conclusionsThis study did not observe significant effects of low to moderate alcohol consumption during pregnancy on executive functioning at the age of 5 years. Furthermore, only weak and no consistent associations between maternal binge drinking and executive functions were observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.