ArticleBJOG : an international journal of obstetrics and gynaecology2012
The effect of different alcohol drinking patterns in early to mid pregnancy on the child's intelligence, attention, and executive function.
Article in BJOG : an international journal of obstetrics and gynaecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Systematic Review and Meta-analysis of the Relationship Between Exposure to Parental Substance Use and Attention-Deficit/Hyperactivity Disorder in Children.Prevention science : the official journal of the Society for Prevention Research · 2024Pooled it
- A Meta-Analysis of Stressors from the Total Environment Associated with Children's General Cognitive Ability.International journal of environmental research and public health · 2020Pooled it
- Contributions of a Child's Built, Natural, and Social Environments to Their General Cognitive Ability: A Systematic Scoping Review.PloS one · 2016Pooled it
- The effect of moderate gestational alcohol consumption during pregnancy on speech and language outcomes in children: a systematic review.Systematic reviews · 2014Pooled it
- Trial
- Parental factors predicting social deviance and psychological outcomes in offspring: Evidence from the Avon Longitudinal Study of Parents and Children (ALSPAC).Nordisk alkohol- & narkotikatidskrift : NAT · 2024Article
- Low to Moderate Prenatal Alcohol Exposure and Neurodevelopmental Outcomes: A Narrative Review and Methodological Considerations.Alcohol research : current reviews · 2023Review
- Trajectories of prenatal alcohol exposure and behavioral outcomes: Findings from a community-based sample.Drug and alcohol dependence · 2022Article
- Impact of prenatal alcohol exposure on neurodevelopmental outcomes: a systematic review.Health psychology and behavioral medicine · 2022Review
- Pregnancy; an opportunity to return to a healthy lifestyle: a qualitative study.BMC pregnancy and childbirth · 2021Article
- Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with widespread increases in H3K9me2 that do not suppress transcription.Epigenetics & chromatin · 2021Article
- Impact of gestational age on child intelligence, attention and executive function at age 5: a cohort study.BMJ open · 2019Article
- Are Low-to-Moderate Average Alcohol Consumption and Isolated Episodes of Binge Drinking in Early Pregnancy Associated with Facial Features Related to Fetal Alcohol Syndrome in 5-Year-Old Children?Alcoholism, clinical and experimental research · 2019Article
- Is breast feeding associated with offspring IQ at age 5? Findings from prospective cohort: Lifestyle During Pregnancy Study.BMJ open · 2019Observational
- Diet and Lifestyle Before and During Pregnancy - Practical Recommendations of the Germany-wide Healthy Start - Young Family Network.Geburtshilfe und Frauenheilkunde · 2018Article
- Maternal Thyroid Function in Early Pregnancy and Neuropsychological Performance of the Child at 5 Years of Age.The Journal of clinical endocrinology and metabolism · 2018Article
- Ethical challenges in FASD prevention: Scientific uncertainty, stigma, and respect for women's autonomy.Canadian journal of public health = Revue canadienne de sante publique · 2017Article
- Impact of Prenatal and Subsequent Adult Alcohol Exposure on Pro-Inflammatory Cytokine Expression in Brain Regions Necessary for Simple Recognition Memory.Brain sciences · 2017Article
- A modified Timeline Followback assessment to capture alcohol exposure in pregnant women: Application in the Safe Passage Study.Alcohol (Fayetteville, N.Y.) · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo conduct a combined analysis of the estimated effects of maternal average weekly alcohol consumption, and any binge drinking, in early to mid pregnancy on general intelligence, attention, and executive function in 5-year-old children.
designFollow-up study.
settingNeuropsychological testing in four Danish cities 2003-2008. POPULATION: A cohort of 1628 women and their children sampled from the Danish National Birth Cohort.
methodsParticipants were sampled based on maternal alcohol consumption during early pregnancy. At age 5 years, the children were tested for general intelligence, attention, and executive function. The three outcomes were analysed together in a multivariate model to obtain joint estimates and P values for the association of alcohol across outcomes. The effects of low to moderate alcohol consumption and binge drinking in early pregnancy were adjusted for a wide range of potential confounding factors.
main outcome measuresWechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-R), the Test of Everyday Attention for Children at Five (TEACh-5), and the Behavior Rating Inventory of Executive Functions (BRIEF) scores.
resultsMultivariate analyses showed no statistically significant effects arising from average weekly alcohol consumption or any binge drinking, either individually or in combination. These results replicate findings from separate analyses of each outcome variable.
conclusionsThe present study contributes comprehensive methodological and statistical approaches that should be incorporated in future studies of low to moderate alcohol consumption and binge drinking during pregnancy. Furthermore, as no safe level of drinking during pregnancy has been established, the most conservative advice for women is not to drink alcohol during pregnancy. However, the present study suggests that small volumes consumed occasionally may not present serious concern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.