ArticleThe European journal of neuroscience2012
Taste uncoupled from nutrition fails to sustain the reinforcing properties of food.
Article in The European journal of neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Trial
- Deletion of the sodium leak channel NALCN in dopamine neurons alters D2R-mediated signalling and psychostimulant responsiveness.The Journal of physiology · 2026Article
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Salience Signaling and Stimulus Scaling of Ventral Tegmental Area Glutamate Neuron Subtypes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Value-Driven Adaptations of Mesolimbic Dopamine Release Are Governed by Both Model-Based and Model-Free Mechanisms.eNeuro · 2024Article
- Early-life influences of low-calorie sweetener consumption on sugar taste.Physiology & behavior · 2023Review
- Homeostatic Reinforcement Theory Accounts for Sodium Appetitive State- and Taste-Dependent Dopamine Responding.Nutrients · 2023Article
- Food memory circuits regulate eating and energy balance.Current biology : CB · 2023Article
- Neurotensin neurons in the extended amygdala control dietary choice and energy homeostasis.Nature neuroscience · 2022Article
- Early-life low-calorie sweetener consumption disrupts glucose regulation, sugar-motivated behavior, and memory function in rats.JCI insight · 2022Article
- Dopamine subsystems that track internal states.Nature · 2022Article
- Effects of nucleus accumbens insulin inactivation on microstructure of licking for glucose and saccharin in male and female rats.Physiology & behavior · 2022Article
- Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Age-dependent effects of protein restriction on dopamine release.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Nutrient-conditioned intake stimulation does not require a distinctive flavor cue in rats.Appetite · 2020Article
- Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity.Neuron · 2020Article
- Article
- Separating Probability and Reversal Learning in a Novel Probabilistic Reversal Learning Task for Mice.Frontiers in behavioral neuroscience · 2019Article
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.Frontiers in integrative neuroscience · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Recent findings suggest the reward system encodes metabolic value independent of taste, provoking speculation that the hedonic value of taste could be derived from nutritional value as a secondary appetitive property. We therefore dissociated and compared the impact of nutrition and taste on appetitive behavior in several paradigms. Though taste alone induces preference and increased consumption, in the absence of nutritional value its reinforcing properties are greatly diminished and it does not, like sucrose, induce increased responding over time. In agreement with behavioral data, saccharin-evoked (but not sucrose-evoked) dopamine release is greatly attenuated following pre-exposure, suggesting that nutritional value is critical for dopamine-mediated reward and reinforcement. Further supporting the primacy of nutrition over taste, genetically increased dopaminergic tone enhances incentive associated with nutritional value with minimal impact on taste-based, hedonic incentive. Overall, we suggest that the sensory-hedonic incentive value associated with taste functions as a conditioned stimulus that requires nutritional value to sustainably organize appetitive behavior.
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