ArticleJournal of geriatric oncology2012
Comparison of Scoring Methods for ACE-27: Simpler Is Better.
Article in Journal of geriatric oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Dose-Escalated Radiation Alone or in Combination With Short-Term Total Androgen Suppression for Intermediate-Risk Prostate Cancer: Patient-Reported Outcomes From NRG/Radiation Therapy Oncology Group 0815 Randomized Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Trial
- Counting co-occurring diseases to predict mortality is as accurate as multimorbidity indices: an external validation study.Age and ageing · 2026Article
- Predictive value of three insulin resistance surrogate indices for symptomatic hypoglycemia risk in hospitalized patients with type 2 diabetes: a retrospective cohort study.BMC endocrine disorders · 2026Article
- Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma.Cancer causes & control : CCC · 2025Article
- Developing a platform to investigate the heterogeneity of outcomes for patients with ovarian cancer.BMJ open quality · 2025Article
- Is early-onset colorectal cancer an evolving pandemic? Real-world data from a tertiary cancer center.The oncologist · 2024Article
- The total amount of fluid administered is associated with postoperative complications in head and neck cancer surgery.World journal of otorhinolaryngology - head and neck surgery · 2023Article
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- Oncological outcomes after pancreatoduodenectomy for pancreatic ductal adenocarcinoma in octogenarians: case-control study.BJS open · 2023Article
- Article
- Generating Practice-Based Evidence in the Use of Guideline-Recommended Combination Therapy for Secondary Prevention of Acute Myocardial Infarction.Pharmacy (Basel, Switzerland) · 2022Article
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- Prognostic Value of Comorbidity for Patients with Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy.Cancers · 2022Article
- Association of baseline self-reported fatigue with overall survival after stereotactic body radiation therapy for localized prostate cancer.Frontiers in oncology · 2022Article
- Risk-Stratified Pancreatectomy Clinical Pathway Implementation and Delayed Gastric Emptying.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Disparities in adherence to head and neck cancer follow-up guidelines.The Laryngoscope · 2019Article
- Free Flaps for Advanced Oral Cancer in the "Older Old" and "Oldest Old": A Retrospective Multi-Institutional Study.Frontiers in oncology · 2019Article
- The influence of comorbidity on the postoperative survival in elderly (≥ 75 years old) with lung cancer.General thoracic and cardiovascular surgery · 2018Observational
- Development of a New Clinical Severity Staging System for Patients With Nonmetastatic Papillary Thyroid Carcinoma.JAMA otolaryngology-- head & neck surgery · 2017Article
- Activity of weekly paclitaxel-cetuximab chemotherapy in unselected patients with recurrent/metastatic head and neck squamous cell carcinoma: prognostic factors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo examine the prognostic value of different comorbidity coding schemes for predicting survival of newly diagnosed elderly cancer patients. MATERIALS AND
methodsWe analyzed data from 8,867 patients aged 65 years of age or older, newly diagnosed with cancer. Comorbidities present at the time of diagnosis were collected using the Adult Comorbidity Evaluation-27 index (ACE-27). We examined multiple scoring schemes based on the individual comorbidity ailments, and their severity rating. Harrell's c index and Akaike Information Criterion (AIC) were used to evaluate the performance of the different comorbidity models.
resultsComorbidity led to an increase in c index from 0.771 for the base model to 0.782 for a model that included indicator variables for every ailment. The prognostic value was however much higher for prostate and breast cancer patients. A simple model which considered linear scores from 0 to 3 per ailment, controlling for cancer type, was optimal according to AIC.
conclusionThe presence of comorbidity impacts on the survival of elderly cancer patients, especially for less lethal cancers, such as prostate and breast cancers. Different ailments have different impacts on survival, necessitating the use of different weights per ailment in a simple summary score of the ACE-27.
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Registered trials
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