ArticleThe Journal of infectious diseases2012
Projecting the benefits of antiretroviral therapy for HIV prevention: the impact of population mobility and linkage to care.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions to improve or facilitate linkage to or retention in pre-ART (HIV) care and initiation of ART in low- and middle-income settings--a systematic review.Journal of the International AIDS Society · 2014Pooled it
- HIV testing and linkage to ART following secondary distribution of HIV self-test kits to male partners of women living with HIV: a pilot randomized control trial in Mpumalanga, South Africa.Journal of the International AIDS Society · 2022Trial
- Short-Term Mobility and Risky Sexual Behaviors Among Men Who Have Sex with Men in Guangdong, China.AIDS and behavior · 2025Article
- Understanding effective post-test linkage strategies for HIV prevention and care: a scoping review.Journal of the International AIDS Society · 2024Article
- Article
- Investigating clinic transfers among HIV patients considered lost to follow-up to improve understanding of the HIV care cascade: Findings from a cohort study in rural north-eastern South Africa.PLOS global public health · 2022Article
- Migration in Namibia and its association with HIV acquisition and treatment outcomes.PloS one · 2021Article
- Factors associated with self-reported HIV testing in the Dominican Republic.International journal of STD & AIDS · 2020Article
- The differential impacts of non-locally acquired infections and treatment interventions on heterosexual HIV transmission in Hong Kong.PloS one · 2020Article
- Mobility and its Effects on HIV Acquisition and Treatment Engagement: Recent Theoretical and Empirical Advances.Current HIV/AIDS reports · 2019Review
- Using big data analytics to improve HIV medical care utilisation in South Carolina: A study protocol.BMJ open · 2019Article
- Article
- Gendered dimensions of population mobility associated with HIV across three epidemics in rural Eastern Africa.Health & place · 2019Observational
- Effect of ART scale-up and female migration intensity on risk of HIV acquisition: results from a population-based cohort in KwaZulu-Natal, South Africa.BMC public health · 2019Observational
- Article
- "I attend at Vanguard and I attend here as well": barriers to accessing healthcare services among older South Africans with HIV and non-communicable diseases.International journal for equity in health · 2018Article
- Bringing population mobility into focus to achieve HIV prevention goals.Journal of the International AIDS Society · 2018Article
- Linkage to care, mobility and retention of HIV-positive postpartum women in antiretroviral therapy services in South Africa.Journal of the International AIDS Society · 2018Article
- Population mobility associated with higher risk sexual behaviour in eastern African communities participating in a Universal Testing and Treatment trial.Journal of the International AIDS Society · 2018Article
- The missing 27.AIDS (London, England) · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundRecent mathematical models suggested that frequent human immunodeficiency virus (HIV) testing with immediate initiation of antiretroviral therapy (ART) to individuals with a positive test result could profoundly curb transmission. The debate about ART as prevention has focused largely on parameter values. We aimed to evaluate structural assumptions regarding linkage to care and population mobility, which have received less attention.
methodsWe modified the linkage structure of published models of ART as prevention, such that individuals who decline initial testing or treatment do not link to care until late-stage HIV infection. We then added population mobility to the models. We populated the models with demographic, clinical, immigration, emigration, and linkage data from a South African township.
resultsIn the refined linkage model, elimination of HIV transmission (defined as an incidence of <0.1%) did not occur by 30 years, even with optimistic assumptions about the linkage rate. Across a wide range of estimates, models were more sensitive to structural assumptions about linkage than to parameter values. Incorporating population mobility further attenuated the reduction in incidence conferred by ART as prevention.
conclusionsLinkage to care and population mobility are critical features of ART-as-prevention models. Clinical trials should incorporate relevant data on linkage to care and migration to evaluate the impact of this strategy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.