Trial reportDigestive diseases and sciences2012
Colonoscopy preparation: polyethylene glycol with Gatorade is as safe and efficacious as four liters of polyethylene glycol with balanced electrolytes.
Trial report in Digestive diseases and sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01170754 (A Prospective, Randomized Controlled Trial Comparing the Efficacy and Patient Tolerability of Miralax), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized Controlled Trial Comparing the Efficacy and Patient Tolerability of Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can adjuncts to bowel preparation for colonoscopy improve patient experience and result in superior bowel cleanliness? A systematic review and meta-analysis.United European gastroenterology journal · 2020Pooled it
- The efficacy and tolerability of sports drink versus water in bowel preparations: a randomised controlled study.Trials · 2022Trial
- Polyethylene Glycol-3350 (Miralax®)+1.9-L sports drink (Gatorade®)+2 tablets of bisacodyl results in inferior bowel preparation for colonoscopy compared with Polyethylene Glycol-Ascorbic Acid (MoviPrep®).The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Trial
- [Early outcomes of elective surgery for colon cancer with preoperative mechanical bowel preparation: a randomized clinical trial].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017Trial
- Bacterial Decontamination: Bowel Preparation and Chlorhexidine Bathing.Clinics in colon and rectal surgery · 2023Review
- Anaphylaxis to Pfizer/BioNTech mRNA COVID-19 Vaccine in a Patient With Clinically Confirmed PEG Allergy.Frontiers in allergy · 2021Article
- Comparing the Real-World Effectiveness of Competing Colonoscopy Preparations: Results of a Prospective Trial.The American journal of gastroenterology · 2019Article
- Optimal Bowel Cleansing for Colonoscopy in the Elderly Patient.Drugs & aging · 2017Article
- Bowel cleansing before colonoscopy: Balancing efficacy, safety, cost and patient tolerance.World journal of gastrointestinal endoscopy · 2016Review
- Bowel Preparation before Elective Surgery.Clinics in colon and rectal surgery · 2013Review
- Validity of a Web-based educational program to disseminate a standardized bowel preparation rating scale.Journal of clinical gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundFour liters of polyethylene glycol 3350 (PEG) with balanced electrolytes for colonoscopy preparation has had poor acceptance. Another approach is the use of electrolyte-free PEG combined with 1.9 L of Gatorade. Despite its widespread use, there are no data on metabolic safety and minimal data on efficacy. Our aim was to assess the efficacy and electrolyte safety of these two PEG-based preparations.
methodsThis was a prospective, randomized, single-blind, non-inferiority trial. Patients were randomized to 238 g PEG + 1.9 L Gatorade or 4 L of PEG-ELS containing 236 g PEG. Split dosing was not performed. On procedure day blood was drawn for basic chemistries. The primary outcome was preparation quality from procedure photos using the Boston Bowel Preparation Scale.
resultsWe randomized 136 patients (66 PEG + Gatorade, 70 PEG-ELS). There were no differences in preparation scores between the two agents in the ITT analysis (7.2 ± 1.9 for PEG-ELS and 7.0 ± 2.1 for PEG + Gatorade; p = 0.45). BBPS scores were identical for those who completed the preparation and dietary instructions as directed (7.4 ± 1.7 for PEG-ELS, and 7.4 ± 1.8 for PEG + Gatorade; p = 0.98). There were no statistical differences in serum electrolytes between the two preparations. Patients who received PEG + Gatorade gave higher overall satisfaction scores for the preparation experience (p = 0.001), and had fewer adverse effects.
conclusionsUse of 238 g PEG + 1.9 L Gatorade appears to be safe, better tolerated, and non-inferior to 4 L PEG-ELS. This preparation may be especially useful for patients who previously tolerated PEG-ELS poorly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.