Evidence map›Paper›PMID 22711442›Full record

ReviewJournal of tissue engineering and regenerative medicine2014

Development of functional biomaterials with micro- and nanoscale technologies for tissue engineering and drug delivery applications.

Hojae Bae, Hunghao Chu, Faramarz Edalat, Jae Min Cha, Shilpa Sant, Aditya Kashyap, Amir F Ahari, Chung Hoon Kwon, Jason W Nichol, Sam Manoucheri and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of tissue engineering and regenerative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Hydrogel Scaffolds to Deliver Cell Therapies for Wound Healing.Frontiers in bioengineering and biotechnology · 2021
    Review
  7. Review
  8. Article
  9. Micro and nanoscale technologies in oral drug delivery.Advanced drug delivery reviews · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. The production of 3D tumor spheroids for cancer drug discovery.Drug discovery today. Technologies · 2017
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Hojae Bae *Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Hunghao Chu *Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Faramarz Edalat *Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Jae Min ChaCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Shilpa SantCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Aditya KashyapCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Amir F AhariCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Chung Hoon KwonCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Jason W NicholCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Sam ManoucheriCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Behnam ZamanianCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Yadong WangDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Ali KhademhosseiniCenter for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Partners Research Building, 65 Landsdowne Street, Room 252, Cambridge, MA 02139, USA.
Brigham and Women's Hospital · USMassachusetts Institute of Technology · USHarvard–MIT Division of Health Sciences and Technology · USHarvard University · USUniversity of Pittsburgh · USKyung Hee University · KR

Funding

Compliant and strong small arteries engineered in vitroR01HL089658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, YADONG · 2007 to 2016
$3.4M
Microfabricated Vascularized 3D Tissue Engineered ConstructsR01HL092836 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2008 to 2012
$2.4M
Microengineered environments for epithelial-mesenchymal interactions (SysCODE 7RL1DE019024 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2007 to 2011
$1.9M
High-Throughput Analysis of Cell Response to Chemical LibrariesR21EB009196 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2009 to 2010
$485k
ENGINEERING OF THE MURINE EMBRYONIC STEM CELL MICROENVIRONMENTR21EB007249 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2007 to 2008
$458k
NHLBI NIH HHS HL092836NHLBI NIH HHS R01 HL089658NIBIB NIH HHS EB007249NIBIB NIH HHS EB009196NIDCR NIH HHS DE019024
6 · The paper itself

Abstract

Micro- and nanotechnologies have emerged as potentially effective fabrication tools for addressing the challenges faced in tissue engineering and drug delivery. The ability to control and manipulate polymeric biomaterials at the micron and nanometre scale with these fabrication techniques has allowed for the creation of controlled cellular environments, engineering of functional tissues and development of better drug delivery systems. In tissue engineering, micro- and nanotechnologies have enabled the recapitulation of the micro- and nanoscale detail of the cell's environment through controlling the surface chemistry and topography of materials, generating 3D cellular scaffolds and regulating cell-cell interactions. Furthermore, these technologies have led to advances in high-throughput screening (HTS), enabling rapid and efficient discovery of a library of materials and screening of drugs that induce cell-specific responses. In drug delivery, controlling the size and geometry of drug carriers with micro- and nanotechnologies have allowed for the modulation of parametres such as bioavailability, pharmacodynamics and cell-specific targeting. In this review, we introduce recent developments in micro- and nanoscale engineering of polymeric biomaterials, with an emphasis on lithographic techniques, and present an overview of their applications in tissue engineering, HTS and drug delivery.

Indexed as

Biocompatible MaterialsDrug Delivery SystemsTissue EngineeringHigh-Throughput Screening AssaysTissue ScaffoldsBiocompatible Materialsbiomaterialsdrug deliveryhigh-throughput screeningmicrotechnologynanotechnologytissue engineering

Identifiers

PMID22711442
PMCPMC4199309
OpenAlexW1549453485

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.