ArticleCirculation2012
Depressive symptom clusters and 5-year incidence of coronary artery calcification: the coronary artery risk development in young adults study.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Association of Depression with Subclinical Coronary Atherosclerosis: a Systematic Review.Journal of cardiovascular translational research · 2021Pooled it
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study.European journal of epidemiology · 2025Article
- Gender differences in the relationship between depressive symptoms and diabetes associated with cognitive-affective symptoms.BJPsych open · 2024Article
- Depression and Subclinical Coronary Atherosclerosis in Adults Without Clinical Coronary Artery Disease.Journal of the American Heart Association · 2023Article
- The personality meta-trait of stability and carotid artery atherosclerosis.Journal of personality · 2023Article
- Association of depressive symptom severity with coronary artery calcium: The Dallas heart study.Journal of affective disorders · 2020Article
- Associations between depressive symptoms, cigarette smoking, and cardiovascular health: Longitudinal results from CARDIA.Journal of affective disorders · 2020Article
- Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.Journal of aging and health · 2019Article
- Correlation of clinical features with hs-CRP in TRD patients.Experimental and therapeutic medicine · 2019Article
- Addressing people and place microenvironments in weight loss disparities (APP-Me): Design of a randomized controlled trial testing timely messages for weight loss behavior in low income Black and White Women.Contemporary clinical trials · 2018Article
- Improved Stability of Whole Brain Surface Parcellation with Multi-Atlas Segmentation.Proceedings of SPIE--the International Society for Optical Engineering · 2018Article
- Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals.Arquivos brasileiros de cardiologia · 2017Article
- Interaction between smoking and depressive symptoms with subclinical heart disease in the Coronary Artery Risk Development in Young Adults (CARDIA) study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017Article
- Body mass index moderates the relationship between C-reactive protein and depressive symptoms: evidence from the China Health and Retirement Longitudinal Study.Scientific reports · 2017Article
- The Protective Role of Positive Well-Being in Cardiovascular Disease: Review of Current Evidence, Mechanisms, and Clinical Implications.Current cardiology reports · 2016Review
- Article
- Relation of Persistent Depressive Symptoms to Coronary Artery Calcification in Women Aged 46 to 59 Years.The American journal of cardiology · 2016Article
- Relation of Depressive Symptoms With Coronary Artery Calcium Determined by Electron-Beam Computed Tomography (from the Rancho Bernardo Study).The American journal of cardiology · 2016Article
- Base Rates of Depressive Symptoms in Patients with Coronary Heart Disease: An Individual Symptom Analysis.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBecause depression is a multidimensional construct and few studies have compared the relative importance of its facets in predicting cardiovascular risk, we evaluated the utility of depressive symptom clusters in predicting the 5-year incidence of coronary artery calcification (CAC). METHODS AND
resultsParticipants were 2171 middle-aged adults (58% female; 43% black) from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were free of cardiovascular disease. Depressive symptom clusters (z scores) were measured by questionnaires in 2000 to 2001, and CAC was measured by electron beam computed tomography in 2000 to 2001 and 2005 to 2006. There were 243 cases (11%) of incident CAC, defined as the absence of CAC at baseline and the presence of CAC at follow-up. Total depressive symptoms (odds ratio, 1.16; 95% confidence interval, 1.02-1.33; P=0.03) and the depressed affect cluster (odds ratio, 1.17; 95% confidence interval, 1.03-1.33; P=0.02) predicted incident CAC; however, the somatic, interpersonal distress, low positive affect, and pessimism clusters did not. The depressed affect-incident CAC relationship was independent of age, sex, race, education, and antidepressant use; was similar across sex and racial groups; and was partially accounted for by tobacco use and mean arterial pressure.
conclusionsIn contrast to recent results indicating that the somatic cluster is the most predictive of cardiovascular outcomes, we found that the prospective association between depressive symptoms and incident CAC was driven by the depressed affect cluster. Our findings raise the possibility that there may not be 1 facet of depression that is the most cardiotoxic across all contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.