SynthesisHuman brain mapping2013
Structural abnormalities in the dyslexic brain: a meta-analysis of voxel-based morphometry studies.
Synthesis in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05832060 (Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia), which is not on this map. Cited by 137 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing the Efficacy of tDCS and tRNS to Improve Reading Skills in Children and Adolescents With Dyslexia
Who cites it
137 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Pooled it
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Are there shared neural correlates between dyslexia and ADHD? A meta-analysis of voxel-based morphometry studies.Journal of neurodevelopmental disorders · 2019Pooled it
- Dyslexic brain activation abnormalities in deep and shallow orthographies: A meta-analysis of 28 functional neuroimaging studies.Human brain mapping · 2016Pooled it
- Reading in the brain of children and adults: a meta-analysis of 40 functional magnetic resonance imaging studies.Human brain mapping · 2015Pooled it
- Gray matter atrophy in Parkinson's disease with dementia: evidence from meta-analysis of voxel-based morphometry studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Pooled it
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Pooled it
- A functionally guided approach to the morphometry of occipitotemporal regions in developmental dyslexia: evidence for differential effects in boys and girls.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Segregation of lexical and sub-lexical reading processes in the left perisylvian cortex.PloS one · 2012Trial
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Experience-dependent cortical plasticity in response to formal schooling: Effects on networks for reading and mathematics.Developmental cognitive neuroscience · 2026Article
- A discovery and replication study of dyslexia does not reveal reproducible gray matter volume differences.bioRxiv : the preprint server for biology · 2026Article
- Proprioception and Sensorimotor Regulation Across the Day-Night Cycle in Developmental Dyslexia: Toward an Embodied Perspective.Brain sciences · 2026Review
- Neural Mechanisms Underlying Reading Impairment in Children Learning a Second Language: A Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- White Matter Networks of Phonological Awareness in Chinese Readers.Brain and behavior · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship with literacy development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Toward a Mechanistic Understanding of Reading Difficulties: Deviant Audiovisual Learning Dynamics and Network Connectivity in Children with Poor Reading Skills.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship to literacy development.bioRxiv : the preprint server for biology · 2025Article
- Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
77 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used coordinate-based meta-analysis in order to objectively quantify gray matter abnormalities reported in nine Voxel-Based Morphometry studies of developmental dyslexia. Consistently across studies, reduced gray matter volume in dyslexic readers was found in the right superior temporal gyrus and left superior temporal sulcus. These results were related to findings from previous meta-analyses on functional brain abnormalities in dyslexic readers. Convergence of gray matter reduction and reading-related underactivation was found for the left superior temporal sulcus. Recent studies point to the presence of both functional and structural abnormalities in left temporal and occipito-temporal brain regions before reading onset.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.