ArticleActa diabetologica2013
The gut microbiota profile is associated with insulin action in humans.
Article in Acta diabetologica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases.Gut microbes · 2025Review
- Exercise-induced increase in muscle insulin sensitivity in men is amplified when assessed using a meal test.Diabetologia · 2024Article
- Mapping Research Trends and Hotspots in the Link between Alzheimer's Disease and Gut Microbes over the Past Decade: A Bibliometric Analysis.Nutrients · 2023Review
- Composition of the intestinal microbiota and its variations between the second and third trimesters in women with gestational diabetes mellitus and without gestational diabetes mellitus.Frontiers in endocrinology · 2023Observational
- Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study.International journal of molecular sciences · 2022Article
- Gestational Diabetes Mellitus: The Crosslink among Inflammation, Nitroxidative Stress, Intestinal Microbiota and Alternative Therapies.Antioxidants (Basel, Switzerland) · 2022Review
- The Modulation of Gut Microbiota Composition in the Pathophysiology of Gestational Diabetes Mellitus: A Systematic Review.Biology · 2021Review
- The Role of Dietary Carbohydrates in Gestational Diabetes.Nutrients · 2020Review
- Gut microbiome and cardiometabolic risk.Reviews in endocrine & metabolic disorders · 2019Review
- Review
- Periodontitis induced byGut · 2017Article
- The Life Course Implications of Ready to Use Therapeutic Food for Children in Low-Income Countries.International journal of environmental research and public health · 2017Article
- Associations between hepatic miRNA expression, liver triacylglycerols and gut microbiota during metabolic adaptation to high-fat diet in mice.Diabetologia · 2017Article
- Gut Microbiota-brain Axis.Chinese medical journal · 2016Review
- Metabolic derivatives of alcohol and the molecular culprits of fibro-hepatocarcinogenesis: Allies or enemies?World journal of gastroenterology · 2016Review
- Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients.American journal of translational research · 2016Article
- Probiotics in prevention and treatment of obesity: a critical view.Nutrition & metabolism · 2016Review
- The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood.Clinical medicine insights. Pediatrics · 2016Review
- Circulating microbial RNA and health.Scientific reports · 2015Article
- Influence of high-fat diet on gut microbiota: a driving force for chronic disease risk.Current opinion in clinical nutrition and metabolic care · 2015Review
Corrections and comments
- Erratum issuedFuentes, Eduardo García [corrected to García-Fuentes, Eduardo]
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the gut microbiota in the induction of metabolic diseases has now been increasingly recognized worldwide. Indeed, a specific gut microbiota has been shown to characterize lean versus obese phenotypes both in humans and mice. We have also recently demonstrated that a precise gut microbiota is associated with the host's responsiveness to a high-fat diet. Therefore, we hypothesized that insulin resistance in humans could also be linked to a specific gut microbiota. To this aim, microbial DNA and RNA were extracted from the appendix contents of insulin-resistant versus insulin-sensitive obese subjects, matched for body mass index and age, and analyzed by DNA- and RNA-DGGE. Microbial DNA analysis showed that the patients fully segregated according to their degree of insulin action. Conversely, microbial RNA investigation showed that some degree of homology still existed between insulin-sensitive and insulin-resistant patients. Quantitative trait analysis, ordinary least squares regression, principal components regression, partial least squares, canonical correlation analysis, and canonical correspondence analysis also showed a net separation of the two phenotypes analyzed. We conclude that a specific gut microbial profile is associated with insulin action in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.