ArticleJournal of neurology2012
Dynamics of saccade parameters in multiple sclerosis patients with fatigue.
Article in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Measuring Fatigue in Multiple Sclerosis: A Rapid Review.The patient · 2025Pooled it
- Trial
- Vertical saccadic slowing is associated with fatigue in multiple sclerosis.Fatigue : biomedicine, health & behavior · 2026Article
- Quantitative Analysis of Smooth Pursuit and Saccadic Eye Movements in Multiple Sclerosis.Neurology international · 2026Article
- Advances in ocular motor and pupil biomarkers for neurological disorders.Brain communications · 2026Review
- Impact of post stroke fatigue on saccadic eye movement control and learning through inflammatory mechanisms.Scientific reports · 2025Article
- Quantification of saccadic fatigability and diagnostic efficacy for myasthenia gravis.Journal of neurology · 2024Article
- Metabolic costs of walking and arm reaching in persons with mild multiple sclerosis.Journal of neurophysiology · 2023Article
- Oculomotor analysis to assess brain health: preliminary findings from a longitudinal study of multiple sclerosis using novel tablet-based eye-tracking software.Frontiers in neurology · 2023Article
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Digital Biomarkers in Multiple Sclerosis.Brain sciences · 2021Review
- Vision as oculomotor reward: cognitive contributions to the dynamic control of saccadic eye movements.Cognitive neurodynamics · 2021Review
- Oculomotor Fatigue and Neuropsychological Assessments mirror Multiple Sclerosis Fatigue.Journal of eye movement research · 2020Article
- Eye Movement Evaluation in Multiple Sclerosis and Parkinson's Disease Using a Standardized Oculomotor and Neuro-Ophthalmic Disorder Assessment (SONDA).Frontiers in neurology · 2020Article
- Gray Matter Atrophy to Explain Subclinical Oculomotor Deficit in Multiple Sclerosis.Frontiers in neurology · 2019Article
- Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment.Frontiers in neurology · 2018Review
- Capturing saccades in multiple sclerosis with a digitized test of rapid number naming.Journal of neurology · 2017Article
- [Therapy of fatigue in multiple sclerosis : A treatment algorithm].Der Nervenarzt · 2016Review
- Ultrahigh field MRI in clinical neuroimmunology: a potential contribution to improved diagnostics and personalised disease management.The EPMA journal · 2015Review
- Vision and vision-related outcome measures in multiple sclerosis.Brain : a journal of neurology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is one of the most frequent and disabling symptoms in multiple sclerosis (MS). Its pathophysiology remains poorly understood and objective measures to quantify fatigue are unavailable to date. To investigate whether analysis of ocular motor movements can provide diagnostic information in MS patients with fatigue, 37 MS patients (21 female, age 44 ± 9 years) and 20 age- and gender-matched healthy controls were prospectively recruited. Fatigue was assessed with the fatigue severity scale (FSS). Twenty-five MS patients were fatigued (defined as FSS ≥ 4) and 12 MS patients were not. Subjects performed a saccadic fatigue task that required execution of uniform saccades over a period of 10 min. Saccadic amplitude, latency and peak velocities during the task were analysed and selected parameters were tested in a receiver operating characteristic (ROC) analysis. Fatigued patients showed a significantly larger decrease of saccadic peak velocity and amplitude when compared to patients without fatigue and healthy controls. Furthermore, fatigued patients showed significantly longer latencies compared to non-fatigued patients and healthy controls. Peak velocity change over time and latencies correlated with FSS scores. The best parameter to discriminate between fatigued and non-fatigued patients was peak velocity change over time (ROC; area under the curve = 0.857). Assessment of peak velocity, amplitude and latency in a saccade fatigue task is a promising approach for quantifying fatigue in MS patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.