ArticleNeonatology2012
Use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia: a review of six patients.
Article in Neonatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn.American journal of perinatology · 2017Trial
- Pulse pressure as an early mortality predictor in neonates with congenital diaphragmatic hernia on veno-arterial ECMO.Pediatric surgery international · 2026Article
- Regional lung function in congenital diaphragmatic hernia assessed using electrical impedance tomography.Pediatric research · 2025Observational
- Article
- Global, regional and national trends in the burden of persistent pulmonary hypertension of the newborn and essentials of its management from 1993 to 2023: a scoping review.Frontiers in pediatrics · 2025Review
- Cardiac function in children with congenital diaphragmatic hernia: cardiac strain at birth and at 2-5 weeks of age.Frontiers in pediatrics · 2025Article
- Hemodynamic management of congenital diaphragmatic hernia: the role of targeted neonatal echocardiography.World journal of pediatric surgery · 2024Review
- Diagnosis, management and long term cardiovascular outcomes of phenotypic profiles in pulmonary hypertension associated with congenital diaphragmatic hernia.Frontiers in pediatrics · 2024Review
- Meconium aspiration syndrome: a comprehensive review.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Congenital diaphragmatic hernia.Nature reviews. Disease primers · 2022Review
- Article
- Fetal MRI mediastinal shift angle and respiratory and cardiovascular pharmacological support in newborns with congenital diaphragmatic hernia.European journal of pediatrics · 2022Article
- The heart in congenital diaphragmatic hernia: Knowns, unknowns, and future priorities.Frontiers in pediatrics · 2022Review
- Congenital diaphragmatic hernia: a narrative review of controversies in neonatal management.Translational pediatrics · 2021Review
- Congenital diaphragmatic hernia: current management strategies from antenatal diagnosis to long-term follow-up.Pediatric surgery international · 2020Review
- Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches.Frontiers in pediatrics · 2020Review
- Heart of the Matter? Early Ventricular Dysfunction in Congenital Diaphragmatic Hernia.American journal of respiratory and critical care medicine · 2019Article
- Response to pulmonary vasodilators in infants with congenital diaphragmatic hernia.Pediatric surgery international · 2018Article
- Diminished Cardiac Performance and Left Ventricular Dimensions in Neonates with Congenital Diaphragmatic Hernia.Pediatric cardiology · 2018Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary hypertension and secondary cardiac dysfunction are important contributors of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-3 inhibitor, may be useful in this setting for its combined actions as a pulmonary vasodilator and to improve systolic and diastolic function.
objectivesThis study aimed to assess the effects of milrinone on cardiac function and pulmonary artery pressure in infants with CDH.
methodsA retrospective review of echocardiograms performed on infants with CDH who received milrinone was performed. Tissue Doppler imaging velocities were used to assess systolic and diastolic function. Pulmonary artery pressure was assessed from the pattern and velocity of ductal shunting.
resultsSix infants with CDH and severe pulmonary hypertension were identified. Systolic and diastolic myocardial velocities were reduced in the right ventricle (RV) and interventricular septum (IVS) at baseline. In the 72 h after commencement of milrinone, there was a significant increase in early diastolic myocardial velocities in the RV, accompanied by increasing systolic velocities in the RV and IVS. Oxygenation index was significantly reduced, blood pressure unchanged, and ductal shunt velocity minimally altered over the same time period.
conclusionsMilrinone use was associated with an improvement in systolic and diastolic function in the RV, corresponding to an improvement in clinical status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.