ArticleHypertension (Dallas, Tex. : 1979)2012
Dahl salt-sensitive rats are protected against vascular defects related to diet-induced obesity.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
- Preclinical animal models of lower urinary tract dysfunction associated with metabolic syndrome.Nature reviews. Urology · 2026Review
- Female Dahl, but Not SS13Research square · 2026Article
- Sympathetic nerves are sparsely distributed in rat mesenteric perivascular adipose tissue.Frontiers in physiology · 2025Article
- A cell atlas of thoracic aortic perivascular adipose tissue: a focus on mechanotransducers.American journal of physiology. Heart and circulatory physiology · 2024Article
- Animal models of heart failure with preserved ejection fraction (HFpEF): from metabolic pathobiology to drug discovery.Acta pharmacologica Sinica · 2024Review
- A Cell Atlas of Thoracic Aortic Perivascular Adipose Tissue: a focus on mechanotransducers.bioRxiv : the preprint server for biology · 2023Article
- Chemerin is resident to vascular tunicas and contributes to vascular tone.American journal of physiology. Heart and circulatory physiology · 2023Article
- Divergence of Chemerin Reduction by an ATS9R Nanoparticle Targeting Adipose Tissue In Vitro vs. In Vivo in the Rat.Biomedicines · 2022Article
- Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats.Renal failure · 2021Article
- Modulation of p66Shc impairs cerebrovascular myogenic tone in low renin but not low nitric oxide models of systemic hypertension.American journal of physiology. Heart and circulatory physiology · 2021Article
- Male and female high-fat diet-fed Dahl SS rats are largely protected from vascular dysfunctions: PVAT contributions reveal sex differences.American journal of physiology. Heart and circulatory physiology · 2021Article
- Fetal programming effects of pentaerythritol tetranitrate in a rat model of superimposed preeclampsia.Journal of molecular medicine (Berlin, Germany) · 2020Article
- Different blood pressure responses in hypertensive rats following chemerin mRNA inhibition in dietary high fat compared to dietary high-salt conditions.Physiological genomics · 2019Article
- Impact of obesity as an independent risk factor for the development of renal injury: implications from rat models of obesity.American journal of physiology. Renal physiology · 2019Review
- Sex Differences in Renal Inflammation and Injury in High-Fat Diet-Fed Dahl Salt-Sensitive Rats.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Genome-wide map of proximity linkage to renin proximal promoter in rat.Physiological genomics · 2018Article
- Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.American journal of physiology. Renal physiology · 2016Article
- Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Obesity-associated hypertension: recent progress in deciphering the pathogenesis.Hypertension (Dallas, Tex. : 1979) · 2014Review
- Response to "Does angiotensin-dependent superoxide production help to prevent salt-induced endothelial dysfunction in 2 kidney-1 clip hypertensive rats?".American journal of hypertension · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Obesity increases plasma renin activity and angiotensin II levels, leading to vascular damage, elevated blood pressure, diabetes mellitus, and renal damage. Because genetic deletion of crucial parts of the renin-angiotensin system protect against obesity-related cardiovascular defects, we hypothesized that Dahl salt-sensitive (SS) rats, a model of chronically low plasma renin activity and angiotensin II levels, would be protected against vascular defects during diet-induced obesity compared with SS.13(BN) consomic rats showing normal renin-angiotensin system regulation. We evaluated vascular function in middle cerebral arteries of SS or SS.13(BN) rats fed high-fat (45% kcal from fat) versus normal-fat diet for 15 to 20 weeks from weaning. Endothelium-dependent relaxation in response to acetylcholine (10(-8) to 10(-4) mol/L) was restored in middle cerebral arteries of high-fat SS rats versus normal-fat diet controls, whereas vasodilation to acetylcholine was dramatically reduced in high-fat SS 13(BN) rats versus normal-fat diet controls. These findings support the hypothesis that physiological levels of angiotensin II play an important role in maintaining normal vascular relaxation in cerebral arteries and suggest that the cerebral vasculature of the SS rat model is genetically protected against endothelial dysfunction in diet-induced obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.