ArticleCerebral cortex (New York, N.Y. : 1991)2013
Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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91 citing papers in PubMed, 198 citations in OpenAlex.
- Random positions of dendritic spines in human cerebral cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Tracking the morphological evolution of neuronal dendrites by first-passage analysis.Biophysical journal · 2026Article
- A mouse brain atlas based on dendritic microenvironments.Nature neuroscience · 2026Article
- Enhanced Distal Signaling in Human Hippocampal Neurons despite Lower Intrinsic Excitability.Research square · 2025Article
- Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses.PLoS computational biology · 2025Article
- Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice.Brain structure & function · 2025Article
- Of mice and men: Dendritic architecture differentiates human from mouse neuronal networks.iScience · 2025Article
- Principles for Dendritic Spine Size and Density in Human and Mouse Cortical Pyramidal Neurons.The Journal of comparative neurology · 2025Article
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- Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range.eLife · 2025Article
- Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range.bioRxiv : the preprint server for biology · 2025Article
- Distribution of spine classes shows intra-neuronal dendritic heterogeneity in mouse cortex.Neurophotonics · 2025Article
- Dendritic Spines of Layer 5 Pyramidal Neurons of the Aging Somatosensory Cortex Exhibit Reduced Volumetric Remodeling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity.Nature neuroscience · 2024Article
- Dendritic spine head diameter predicts episodic memory performance in older adults.Science advances · 2024Article
- Volume electron microscopy analysis of synapses in primary regions of the human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.Disease models & mechanisms · 2024Article
- A modular framework for multi-scale tissue imaging and neuronal segmentation.Nature communications · 2024Article
- Key morphological features of human pyramidal neurons.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
31 more citing papers are in PubMed but not listed here.
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5 authors at 3 institutions in 2 countries.
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Abstract
Dendritic spines of pyramidal neurons are targets of most excitatory synapses in the cerebral cortex. Recent evidence suggests that the morphology of the dendritic spine could determine its synaptic strength and learning rules. However, unfortunately, there are scant data available regarding the detailed morphology of these structures for the human cerebral cortex. In the present study, we analyzed over 8900 individual dendritic spines that were completely 3D reconstructed along the length of apical and basal dendrites of layer III pyramidal neurons in the cingulate cortex of 2 male humans (aged 40 and 85 years old), using intracellular injections of Lucifer Yellow in fixed tissue. We assembled a large, quantitative database, which revealed a major reduction in spine densities in the aged case. Specifically, small and short spines of basal dendrites and long spines of apical dendrites were lost, regardless of the distance from the soma. Given the age difference between the cases, our results suggest selective alterations in spines with aging in humans and indicate that the spine volume and length are regulated by different biological mechanisms.
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