Evidence map›Paper›PMID 22710576›Full record

ArticleThe American journal of gastroenterology2012

Serrated lesions of the colorectum: review and recommendations from an expert panel.

Douglas K Rex, Dennis J Ahnen, John A Baron, Kenneth P Batts, Carol A Burke, Randall W Burt, John R Goldblum, José G Guillem, Charles J Kahi, Matthew F Kalady and 9 more

2 registry-linked trialsAbstract readConsensus Development Conference, NIH
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 474 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
474citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02876133 naunknown statusnot on this mapstarted 2016, after this paper: background citation

Improving Colorectal Cancer Screening: Using Narrow Band Imaging for Colonic Sessile Serrated Lesions

TypeinterventionalSponsorHospital Beatriz ÂngeloRan2016 to 2019Enrolled987ConditionsColon Cancer, Colon Sessile Serrated Adenoma/PolypArmsnarrow band imaging withdrawal, white light withdrawal
NCT04889352 nacompletednot on this mapstarted 2021, after this paper: background citation

Optimizing Timing of Follow-up Colonoscopy: A Pilot Cluster Randomized Trial to Test the Utility of a Knowledge Translation Tool

TypeinterventionalSponsorUniversity of ManitobaRan2021 to 2022Enrolled29ConditionsColo-rectal Cancer, Colon Polyp, Colonic Polyp, Rectal PolypArmsAccess to colonoscopy web app
3 · Its place in the literature

Who cites it

474 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024
    Guideline
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Prevalence of missed lesions in patients with inadequate bowel preparation through a very early repeat colonoscopy.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2022
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Article
  20. Review

414 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Douglas K RexIndiana University, Indianapolis, Indiana, USA.
Dennis J Ahnen
John A Baron
Kenneth P Batts
Carol A Burke
Randall W Burt
John R Goldblum
José G Guillem
Charles J Kahi
Matthew F Kalady
Michael J O'Brien
Robert D Odze
Shuji Ogino
Susan Parry
Dale C Snover
Emina Emilia Torlakovic
Paul E Wise
Joanne Young
James Church

Funding

Epigenetic Events and Colorectal Cancer EpidemiologyR01CA151993 · NCI · DANA-FARBER CANCER INST · PI OGINO, SHUJI · 2010 to 2014
$2.6M
NCI NIH HHS R01 CA151993
6 · The paper itself

Abstract

Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and account for a disproportionate fraction of cancer identified after colonoscopy. We sought to provide guidance for the clinical management of serrated colorectal lesions based on current evidence and expert opinion regarding definitions, classification, and significance of serrated lesions. A consensus conference was held over 2 days reviewing the topic of serrated lesions from the perspectives of histology, molecular biology, epidemiology, clinical aspects, and serrated polyposis. Serrated lesions should be classified pathologically according to the World Health Organization criteria as hyperplastic polyp, sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia, or traditional serrated adenoma (TSA). SSA/P and TSA are premalignant lesions, but SSA/P is the principal serrated precursor of CRCs. Serrated lesions have a distinct endoscopic appearance, and several lines of evidence suggest that on average they are more difficult to detect than conventional adenomatous polyps. Effective colonoscopy requires an endoscopist trained in the endoscopic appearance of serrated lesions. We recommend that all serrated lesions proximal to the sigmoid colon and all serrated lesions in the rectosigmoid > 5 mm in size, be completely removed. Recommendations are made for post-polypectomy surveillance of serrated lesions and for surveillance of serrated polyposis patients and their relatives.

Indexed as

Colonic DiseasesRectal DiseasesAdenomaColonColonic PolypsColorectal NeoplasmsHumansRectum

Identifiers

PMID22710576
PMCPMC3629844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.