Evidence map›Paper›PMID 22710361›Full record

ReviewCurrent opinion in neurology2012

Functional brain networks in movement disorders: recent advances.

Florian Holtbernd, David Eidelberg

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  2. Pooled it
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  12. Observational
  13. Article
  14. Asymmetrical pedaling patterns in Parkinson's disease patients.Clinical biomechanics (Bristol, Avon) · 2014
    Article
  15. Involuntary movement in pediatric moyamoya disease patients: consideration of pathogenetic mechanism using neuroimaging studies.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014
    Article
  16. Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Florian HoltberndCenter for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA.
David Eidelberg
Feinstein Institute for Medical Research · US

Funding

Statistics and Data Management CoreP50NS071675 · NINDS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI FEIGIN, ANDREW · 2010 to 2014
$9.3M
Structure-Function Relationships in Dystonia: A Network ApproachR01NS072514 · NINDS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI EIDELBERG, DAVID · 2011 to 2014
$2.4M
Mentorship and Development Program for Biomedical TraineesDP7OD018428 · OD · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI FRIEDLANDER, MICHAEL J · 2013 to 2017
$1.8M
NIH HHS DP7 OD018428NINDS NIH HHS P50 NS071675NINDS NIH HHS P50NS071675NINDS NIH HHS R01 NS072514NINDS NIH HHS R01NS072514
6 · The paper itself

Abstract

purpose of reviewDifferent neuroimaging techniques have been used to identify disease-specific functional brain networks in Parkinson's disease, atypical parkinsonian syndromes, and other movement disorders. This review highlights recent advances in network imaging and its clinical applications in movement disorders. RECENT

findingsPositron emission tomography and functional MRI studies have revealed distinct, abnormal metabolic brain networks and altered interregional connectivity in Parkinson's disease and related movement disorders. Network-level functional changes have been found to correlate with disease severity and progression. Moreover, network-based categorization algorithms are proving useful in enhancing the accuracy of clinical diagnosis in patients with early symptoms and in providing objective evidence of treatment response. SUMMARY: Although in most movement disorders the predominant histopathology involves the basal ganglia, including the substantia nigra, functional changes in relevant neural circuits are not limited to these structures. The current advances in functional brain imaging have contributed to a better pathophysiological understanding of movement disorders as complex alterations of widespread functional brain networks. The promising findings from recent studies may help to establish new and reliable biomarkers to monitor disease progression and treatment effects in future clinical trials.

Indexed as

BrainCognition DisordersHumansMovement DisordersNerve NetNeural PathwaysNeuroimaging

Identifiers

PMID22710361
PMCPMC4554600
OpenAlexW2312244472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.