ArticleCritical care medicine2012
BCL2 genetic variants are associated with acute kidney injury in septic shock*.
Article in Critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Genetic association studies in critically ill patients: a systematic review.EBioMedicine · 2025Pooled it
- Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2020Pooled it
- Genetic predisposition to acute kidney injury--a systematic review.BMC nephrology · 2015Pooled it
- Association between SIRT-1 and SERPINA4 gene polymorphisms and the risk of idiopathic nephrotic syndrome among Egyptian children.Molecular biology reports · 2025Article
- The multifaceted role of kallistatin in human diseases: mechanistic insights and translational potential.Frontiers in cardiovascular medicine · 2025Review
- Article
- Immunotherapy in the context of sepsis-induced immunological dysregulation.Frontiers in immunology · 2024Review
- Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup.Nature reviews. Nephrology · 2023Review
- Review
- Genetic predisposition may not improve prediction of cardiac surgery-associated acute kidney injury.Frontiers in genetics · 2023Article
- Potential impact of serpin peptidase inhibitor clade (A) member 4 SERPINA4 (rs2093266) and SERPINA5 (rs1955656) genetic variants on COVID-19 induced acute kidney injury.Human gene (Amsterdam, Netherlands) · 2022Article
- Morphogenetic dispositions for variability in acute kidney injury after cardiac surgery: Pilot study.Frontiers in medicine · 2022Article
- Multi-Omics Techniques Make it Possible to Analyze Sepsis-Associated Acute Kidney Injury Comprehensively.Frontiers in immunology · 2022Review
- Genetic Susceptibility to Acute Kidney Injury.Journal of clinical medicine · 2021Review
- The application of omic technologies to research in sepsis-associated acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2021Review
- A Thrombomodulin Promoter Gene Polymorphism, rs2239562, Influences Both Susceptibility to and Outcome of Sepsis.Frontiers in medicine · 2021Article
- CXCL8Biological research · 2019Article
- Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients.Journal of clinical medicine · 2019Article
- Melittin Inducing the Apoptosis of Renal Tubule Epithelial Cells through Upregulation of Bax/Bcl-2 Expression and Activation of TNF-BioMed research international · 2019Article
- Long non-coding RNA PlncRNA-1 regulates cell proliferation, apoptosis, and autophagy in septic acute kidney injury by regulating BCL2.International journal of clinical and experimental pathology · 2018Article
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9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveAcute kidney injury frequently complicates septic shock and independently predicts mortality in this population. Clinical factors alone do not entirely account for differences in risk of acute kidney injury between patients. Genetic variants are likely to explain this differential susceptibility. To identify genetic variants linked to acute kidney injury susceptibility, we conducted a high-density genotyping association study in a large population of patients with septic shock.
designRetrospective study.
settingTertiary academic medical center. PATIENTS: One thousand two hundred and sixty-four patients with septic shock were analyzed to elucidate clinical risk factors associated with the development of acute kidney injury. Among them, 887 Caucasian patients were randomly split into discovery and validation cohorts and genotyped using the Illumina Human-CVD BeadChip (Illumina, San Diego, CA).
interventionsNone. MEASUREMENTS AND MAIN
resultsSix hundred and twenty-seven of the 1,264 patients with septic shock and 441 of the 887 patients with genotyping data developed acute kidney injury within the first 72 hrs of intensive care unit admission. Five single nucleotide polymorphisms were associated with acute kidney injury in both the discovery and validation cohorts. Two of these were in the BCL2 gene and both were associated with a decreased risk of acute kidney injury (rs8094315: odds ratio 0.61, p = .0002; rs12457893: odds ratio 0.67, p = .0002, both for combined data). Bcl-2 is involved in the apoptosis pathway, which has previously been implicated in acute kidney injury. Another single nucleotide polymorphism was in the SERPINA4 gene, whose protein product, kallistatin, has been linked to apoptosis in the kidney.
conclusionsLarge-scale genotyping reveals two single nucleotide polymorphisms in the BCL2 gene and a single nucleotide polymorphism in the SERPINA4 gene associated with a decreased risk of developing acute kidney injury, supporting the putative role of apoptosis in the pathogenesis of acute kidney injury.
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