ArticleGastroenterology2012
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.
Article in Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Primary Immunodeficiencies Associated With Early-Onset Inflammatory Bowel Disease in Southeast and East Asia.Frontiers in immunology · 2021Pooled it
- Branched actin networks mediate macrophage-dependent host-microbiota homeostasis.Science (New York, N.Y.) · 2025Article
- Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice.Mucosal immunology · 2025Article
- IL-17-Dependent Dysregulated Cutaneous Immune Homeostasis in the Absence of the Wiskott-Aldrich Syndrome Protein.Frontiers in immunology · 2022Article
- Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome.The Journal of allergy and clinical immunology · 2018Article
- WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.Nature communications · 2018Article
- Plasmacytoid Dendritic Cells Are Largely Dispensable for the Pathogenesis of Experimental Inflammatory Bowel Disease.Frontiers in immunology · 2018Article
- Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells.Genome medicine · 2017Article
- Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model?Cellular and molecular gastroenterology and hepatology · 2017Review
- Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis.Inflammatory bowel diseases · 2016Article
- Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin-10 signalling.Immunology · 2016Article
- Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- Very early-onset inflammatory bowel disease: gaining insight through focused discovery.Inflammatory bowel diseases · 2015Review
- Gut microbiome and anticancer immune response: really hot Sh*t!Cell death and differentiation · 2015Review
- Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn's-like ileitis.Mucosal immunology · 2014Article
- Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.Immunity · 2014Article
- Colitis and colon cancer in WASP-deficient mice require helicobacter species.Inflammatory bowel diseases · 2013Article
- Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells.The Journal of experimental medicine · 2013Article
- Animal models of ulcerative colitis and their application in drug research.Drug design, development and therapy · 2013Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsImmunodeficiency and autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton. Development of colitis in WASP-deficient mice requires lymphocytes; transfer of T cells is sufficient to induce colitis in immunodeficient mice. We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system.
methodsNaïve and/or regulatory CD4(+) T cells were transferred from 129 SvEv mice into RAG-2-deficient (RAG-2 KO) mice or mice lacking WASP and RAG-2 (WRDKO). Animals were observed for the development of colitis; effector and regulatory functions of innate immune and T cells were analyzed with in vivo and in vitro assays.
resultsTransfer of unfractionated CD4(+) T cells induced severe colitis in WRDKO, but not RAG-2 KO, mice. Naïve wild-type T cells had higher levels of effector activity and regulatory T cells had reduced suppressive function when transferred into WRDKO mice compared with RAG-2 KO mice. Regulatory T-cell proliferation, generation, and maintenance of FoxP3 expression were reduced in WRDKO recipients and associated with reduced numbers of CD103(+) tolerogenic dendritic cells and levels of interleukin-10. Administration of interleukin-10 prevented induction of colitis following transfer of T cells into WRDKO mice.
conclusionsDefective interactions between WASP-deficient innate immune cells and normal T cells disrupt mucosal regulation, potentially by altering the functions of tolerogenic dendritic cells, production of interleukin-10, and homeostasis of regulatory T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.