ReviewFEBS letters2012
Synthetic constructs in/for the environment: managing the interplay between natural and engineered Biology.
Review in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria.Nucleic acids research · 2026Article
- From domination to partnership : Lab-trained microorganisms for environmental bioremediation.EMBO reports · 2026Article
- Information storage across a microbial community using universal RNA barcoding.Nature biotechnology · 2026Article
- An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing.Science and engineering ethics · 2026Article
- Design and regulation of engineered bacteria for environmental release.Nature microbiology · 2025Review
- Synthetic Ecosystems: From the Test Tube to the Biosphere.ACS synthetic biology · 2024Review
- Ecological firewalls for synthetic biology.iScience · 2022Article
- How To Quantify a Genetic Firewall? A Polarity-Based Metric for Genetic Code Engineering.Chembiochem : a European journal of chemical biology · 2021Article
- Controlling the Implementation of Transgenic Microbes: Are We Ready for What Synthetic Biology Has to Offer?Molecular cell · 2020Review
- Synthetic Biology for Terraformation Lessons from Mars, Earth, and the Microbiome.Life (Basel, Switzerland) · 2020Article
- Evolutionary tinkering vs. rational engineering in the times of synthetic biology.Life sciences, society and policy · 2018Article
- The evolving interface between synthetic biology and functional metagenomics.Nature chemical biology · 2018Review
- Population dynamics of synthetic terraformation motifs.Royal Society open science · 2018Article
- Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications.Journal of biological engineering · 2018Review
- Synthetic microbiology: from analogy to methodology.Microbial biotechnology · 2017Article
- Development of SimCells as a novel chassis for functional biosensors.Scientific reports · 2017Article
- Synthetic biology approaches to biological containment: pre-emptively tackling potential risks.Essays in biochemistry · 2016Review
- Bioremediation at a global scale: from the test tube to planet Earth.Microbial biotechnology · 2016Review
- Prospective Technology Assessment of Synthetic Biology: Fundamental and Propaedeutic Reflections in Order to Enable an Early Assessment.Science and engineering ethics · 2016Article
- Genomic Recoding Broadly Obstructs the Propagation of Horizontally Transferred Genetic Elements.Cell systems · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The plausible release of deeply engineered or even entirely synthetic/artificial microorganisms raises the issue of their intentional (e.g. bioremediation) or accidental interaction with the Environment. Containment systems designed in the 1980s-1990s for limiting the spread of genetically engineered bacteria and their recombinant traits are still applicable to contemporary Synthetic Biology constructs. Yet, the ease of DNA synthesis and the uncertainty on how non-natural properties and strains could interplay with the existing biological word poses yet again the challenge of designing safe and efficacious firewalls to curtail possible interactions. Such barriers may include xeno-nucleic acids (XNAs) instead of DNA as information-bearing molecules, rewriting the genetic code to make it non-understandable by the existing gene expression machineries, and/or making growth dependent on xenobiotic chemicals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.