ReviewFEBS letters2012
Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads.
Review in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Tanshinone IIA Attenuates Pulmonary Fibrosis via Dual Inhibition of JNK and Smad Signaling.Antioxidants (Basel, Switzerland) · 2026Article
- SMAD2 ubiquitination through PY motif regulates skeletal muscle mass and fibrotic degeneration.Scientific reports · 2026Article
- The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling.Cancers · 2020Review
- Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β.Rheumatology (Oxford, England) · 2019Article
- Contextual determinants of TGFβ action in development, immunity and cancer.Nature reviews. Molecular cell biology · 2018Review
- The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis.Scientific reports · 2018Article
- SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation.International journal of molecular sciences · 2017Article
- Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer.Frontiers in immunology · 2017Review
- Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.Oncotarget · 2016Article
- Valproic acid (VPA) inhibits the epithelial-mesenchymal transition in prostate carcinoma via the dual suppression of SMAD4.Journal of cancer research and clinical oncology · 2016Article
- Protein Arginine Methyltransferase 1 Methylates Smurf2.Molecules and cells · 2015Article
- Protein monoubiquitylation: targets and diverse functions.Genes to cells : devoted to molecular & cellular mechanisms · 2015Review
- TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients.BMC cancer · 2015Article
- The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.Cellular signalling · 2014Review
- New gene evolution in the bonus-TIF1-γ/TRIM33 family impacted the architecture of the vertebrate dorsal-ventral patterning network.Molecular biology and evolution · 2014Article
- USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.eLife · 2014Article
- Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer.Breast cancer research : BCR · 2014Review
- Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure.American journal of physiology. Heart and circulatory physiology · 2013Article
- Mechanisms of prickle1a function in zebrafish epilepsy and retinal neurogenesis.Disease models & mechanisms · 2013Article
- OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.Nature communications · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following the identification of deubiquitylases required for TGF-β signaling, suggesting that continuous cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. Here we summarize and discuss recent work on Smad mono- and deubiquitylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.