ArticleAntimicrobial agents and chemotherapy2012
Azole preexposure affects the Aspergillus fumigatus population in patients.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Antifungal Susceptibility andMicroorganisms · 2026Article
- Novel cyp51A mutation profile in Aspergillus fumigatus from a patient with systemic lupus erythematosus and limited systemic sclerosis: first clinical case of acquired azole-resistance in Colombia.BMC infectious diseases · 2026Article
- Insights intoJournal of fungi (Basel, Switzerland) · 2024Article
- Triazole resistance inApplied and environmental microbiology · 2024Article
- Pulmonary Aspergillosis in Humboldt Penguins-Susceptibility Patterns and Molecular Epidemiology of Clinical and EnvironmentalAntibiotics (Basel, Switzerland) · 2023Article
- Triazole-Resistance in EnvironmentalJournal of fungi (Basel, Switzerland) · 2021Article
- A Simple Method To Detect Point Mutations in Aspergillus fumigatusAntimicrobial agents and chemotherapy · 2020Article
- Aspergillus fumigatus Clinical Isolates Carrying CYP51A with TR34/L98H/S297T/F495I Substitutions Detected after Four-Year Retrospective Azole Resistance Screening in Brazil.Antimicrobial agents and chemotherapy · 2020Article
- Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.Antimicrobial agents and chemotherapy · 2018Article
- Surveillance for azoles resistance in Aspergillus spp. highlights a high number of amphotericin B-resistant isolates.Mycoses · 2018Article
- Emergence of Echinocandin Resistance Due to a Point Mutation in theAntimicrobial agents and chemotherapy · 2017Article
- Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.Clinical microbiology reviews · 2017Review
- Changes in In Vitro Susceptibility Patterns of Aspergillus to Triazoles and Correlation With Aspergillosis Outcome in a Tertiary Care Cancer Center, 1999-2015.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Review
- Nationwide Surveillance of Azole Resistance in Aspergillus Diseases.Antimicrobial agents and chemotherapy · 2015Article
- Resistance to antifungals that target CYP51.Journal of chemical biology · 2014Review
- Azole resistance in Aspergillus fumigatus from bronchoalveolar lavage fluid samples of patients with chronic diseases.The Journal of antimicrobial chemotherapy · 2013Article
- In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2013Article
- An invisible threat: mutation-mediated resistance to triazole drugs inCurrent fungal infection reports · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although <2 μg/ml using the EUCAST methodology, were associated with two genetic clusters (P < 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.
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