ReviewOrphanet journal of rare diseases2012
Cushing's disease.
Review in Orphanet journal of rare diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Pasireotide treatment significantly reduces tumor volume in patients with Cushing's disease: results from a Phase 3 study.Pituitary · 2020Trial
- Systemic and cardiac pathology induced by a clinically relevant USP8 activating mutation.Disease models & mechanisms · 2026Article
- Article
- M3S-GRPred: a novel ensemble learning approach for the interpretable prediction of glucocorticoid receptor antagonists using a multi-step stacking strategy.BMC bioinformatics · 2025Article
- Pasireotide-induced hyperglycemia in Cushing's disease and Acromegaly: A clinical perspective and algorithms proposal.Frontiers in endocrinology · 2024Review
- Neurosurgical aspects and clinical outcomes on the treatment of Cushing disease in pediatric patients: Case series and literature review.Surgical neurology international · 2023Article
- PitNETs and the gut microbiota: potential connections, future directions.Frontiers in endocrinology · 2023Review
- Glymphatic transport is reduced in rats with spontaneous pituitary tumor.Frontiers in medicine · 2023Article
- Article
- Pituitary adenomas and cerebrovascular disease: A review on pathophysiology, prevalence, and treatment.Frontiers in endocrinology · 2022Review
- Paediatric Cushing's disease: Epidemiology, pathogenesis, clinical management and outcome.Reviews in endocrine & metabolic disorders · 2021Review
- A case of Cushing Syndrome due to accidental intake of dexamethasone: a call for enforcement of regulatory laws.Ghana medical journal · 2021Article
- The Menstrual Disturbances in Endocrine Disorders: A Narrative Review.International journal of endocrinology and metabolism · 2020Review
- Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.Immunity · 2020Article
- Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus).Scientific reports · 2020Article
- Cushing's Disease.Journal of clinical medicine · 2019Review
- Clinical score system in the treatment of Cushing's disease: failure to identify discriminative variables from the German Cushing's Registry.Pituitary · 2019Article
- Low-dose etomidate for the management of severe hypercortisolaemia in different clinical scenarios: a case series and review of the literature.Therapeutic advances in endocrinology and metabolism · 2019Article
- Support Needs of Patients with Cushing's Disease and Cushing's Syndrome: Results of a Survey Conducted in Germany and the USA.International journal of endocrinology · 2018Article
- A retrospective analysis of postoperative hypokalemia in pituitary adenomas after transsphenoidal surgery.PeerJ · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cushing's disease, or pituitary ACTH dependent Cushing's syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood pressure, variable levels of hirsutism. Diagnosis is frequently difficult, and requires a strict algorithm. First-line treatment is based on transsphenoidal surgery, which cures 80% of ACTH-secreting microadenomas. The rate of remission is lower in macroadenomas. Other therapeutic modalities including anticortisolic drugs, radiation techniques or bilateral adrenalectomy will thus be necessary to avoid long-term risks (metabolic syndrome, osteoporosis, cardiovascular disease) of hypercortisolism. This review summarizes potential pathophysiological mechanisms, diagnostic approaches, and therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.