ArticleVirology2012
The roles of SaPI1 proteins gp7 (CpmA) and gp6 (CpmB) in capsid size determination and helper phage interference.
Article in Virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Phage induction of Staphylococcus aureus pathogenicity islands promotes the CRISPR-Cas adaptive immune response.Cell reports · 2026Article
- Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection.PLoS pathogens · 2026Article
- Virion content unpacked by long-read sequencing: stress-induced changes in transmitted staphylococcal mobilome due to phage-satellite interactions.Nucleic acids research · 2025Article
- Capsid redirection mechanism of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Genetics, ecology and evolution of phage satellites.Nature reviews. Microbiology · 2025Review
- Phage parasites targeting phage homologous recombinases provide antiviral immunity.Nature communications · 2025Article
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.Nucleic acids research · 2024Article
- A phage satellite manipulates the viral DNA packaging motor to inhibit phage and promote satellite spread.bioRxiv : the preprint server for biology · 2024Article
- Structure of the Portal Complex from Staphylococcus aureus Pathogenicity Island 1 Transducing Particles In Situ and In Isolation.Journal of molecular biology · 2024Article
- AeLife · 2024Article
- AbioRxiv : the preprint server for biology · 2023Article
- A phage parasite deploys a nicking nuclease effector to inhibit viral host replication.Nucleic acids research · 2022Article
- Staphylococcal self-loading helicases couple the staircase mechanism with inter domain high flexibility.Nucleic acids research · 2022Article
- Article
- Antibacterial particles and predatory bacteria as alternatives to antibacterial chemicals in the era of antibiotic resistance.Current opinion in microbiology · 2021Review
- Phage satellites and their emerging applications in biotechnology.FEMS microbiology reviews · 2021Review
- Shape shifter: redirection of prolate phage capsid assembly by staphylococcal pathogenicity islands.Nature communications · 2021Article
- Staphylococcal phages and pathogenicity islands drive plasmid evolution.Nature communications · 2021Article
- Article
- The gp44 Ejection Protein ofViruses · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
SaPIs are molecular pirates that exploit helper bacteriophages for their own high frequency mobilization. One striking feature of helper exploitation by SaPIs is redirection of the phage capsid assembly pathway to produce smaller phage-like particles with T=4 icosahedral symmetry rather than T=7 bacteriophage capsids. Small capsids can accommodate the SaPI genome but not that of the helper phage, leading to interference with helper propagation. Previous studies identified two proteins encoded by the prototype element SaPI1, gp6 and gp7, in SaPI1 procapsids but not in mature SaPI1 particles. Dimers of gp6 form an internal scaffold, aiding fidelity of small capsid assembly. Here we show that both SaPI1 gp6 (CpmB) and gp7 (CpmA) are necessary and sufficient to direct small capsid formation. Surprisingly, failure to form small capsids did not restore wild-type levels of helper phage growth, suggesting an additional role for these SaPI1 proteins in phage interference.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.