ArticleExperimental physiology2013
Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running.
Article in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Role of ERβ in adipocyte metabolic response to wheel running following ovariectomy.The Journal of endocrinology · 2021Article
- Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.Hormones and behavior · 2020Article
- Aerobic Exercise Training Inhibits Neointimal Formation via Reduction of PCSK9 and LOX-1 in Atherosclerosis.Biomedicines · 2020Article
- Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice.Frontiers in physiology · 2019Article
- Prolonged sitting leg vasculopathy: contributing factors and clinical implications.American journal of physiology. Heart and circulatory physiology · 2017Review
- Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction.American journal of physiology. Endocrinology and metabolism · 2017Article
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017Review
- Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle.Physiological reports · 2016Article
- Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Divergent role of nitric oxide in insulin-stimulated aortic vasorelaxation between low- and high-intrinsic aerobic capacity rats.Physiological reports · 2015Article
- Role of habitual physical activity in modulating vascular actions of insulin.Experimental physiology · 2015Review
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Beneficial paracrine effects of adipocytes from obese rats on cultured endothelial cells.Journal of clinical & translational endocrinology · 2014Article
- Differential regulation of adipose tissue and vascular inflammatory gene expression by chronic systemic inhibition of NOS in lean and obese rats.Physiological reports · 2014Article
- Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine.Physiological genomics · 2013Article
- Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Early vascular changes at the molecular level caused by adoption of a sedentary lifestyle are incompletely characterized. Herein, we employed the rodent wheel-lock model to identify mRNAs in the arterial wall that are responsive to the acute transition from higher to lower levels of daily physical activity. Specifically, we evaluated whether short-term cessation of voluntary wheel running alters vascular mRNA levels in rat conduit arteries previously reported to have marked increases (i.e. iliac artery) versus marked decreases (i.e. renal artery) in blood flow during running. We used young female Wistar rats with free access to voluntary running wheels. Following 23 days of voluntary running (average distance of ∼15 km per night; ∼4.4 h per night), rats in one group were rapidly transitioned to a sedentary state by locking the wheels for 7 days (n = 9; wheel-lock 7 day rats) or remained active in a second group for an additional 7 days (n = 9; wheel-lock 0 day rats). Real-time PCR was conducted on total RNA isolated from iliac and renal arteries to evaluate expression of 25 pro-atherogenic and anti-atherogenic genes. Compared with the iliac arteries of wheel-lock 0 day rats, iliac arteries of wheel-lock 7 day rats exhibited increased expression of TNFR1 (+19%), ET1 (+59%) and LOX-1 (+31%; all P < 0.05). Moreover, compared with renal arteries of wheel-lock 0 day rats, renal arteries of wheel-lock 7 day rats exhibited decreased expression of ETb (-23%), p47phox (-32%) and p67phox (-19%; all P < 0.05). These data demonstrate that cessation of voluntary wheel running for 7 days produces modest, but differential changes in mRNA levels between the iliac and renal arteries of healthy rats. This heterogeneous influence of short-term physical inactivity could be attributed to the distinct alteration in haemodynamic forces between arteries.
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