ArticleJournal of proteome research2012
Constrained de novo sequencing of conotoxins.
Article in Journal of proteome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics withToxins · 2025Article
- Origins, Technological Advancement, and Applications of Peptidomics.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Identification of Conomarphin Variants in theMarine drugs · 2020Article
- Alphabet Projection of Spectra.Journal of proteome research · 2019Article
- Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery.Journal of the American Society for Mass Spectrometry · 2017Article
- A mass graph-based approach for the identification of modified proteoforms using top-down tandem mass spectra.Bioinformatics (Oxford, England) · 2017Article
- Small Packages, Big Returns: Uncovering the Venom Diversity of Small Invertebrate Conoidean Snails.Integrative and comparative biology · 2016Article
- Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp.Marine drugs · 2016Article
- Optimized deep-targeted proteotranscriptomic profiling reveals unexplored Conus toxin diversity and novel cysteine frameworks.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Bioinformatics-Aided Venomics.Toxins · 2015Review
- Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.Future medicinal chemistry · 2014Review
- Discovery, synthesis, and structure-activity relationships of conotoxins.Chemical reviews · 2014Review
- Various conotoxin diversifications revealed by a venomic study of Conus flavidus.Molecular & cellular proteomics : MCP · 2014Article
- Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata.PloS one · 2014Article
- Sequencing-grade de novo analysis of MS/MS triplets (CID/HCD/ETD) from overlapping peptides.Journal of proteome research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
De novo peptide sequencing by mass spectrometry (MS) can determine the amino acid sequence of an unknown peptide without reference to a protein database. MS-based de novo sequencing assumes special importance in focused studies of families of biologically active peptides and proteins, such as hormones, toxins, and antibodies, for which amino acid sequences may be difficult to obtain through genomic methods. These protein families often exhibit sequence homology or characteristic amino acid content; yet, current de novo sequencing approaches do not take advantage of this prior knowledge and, hence, search an unnecessarily large space of possible sequences. Here, we describe an algorithm for de novo sequencing that incorporates sequence constraints into the core graph algorithm and thereby reduces the search space by many orders of magnitude. We demonstrate our algorithm in a study of cysteine-rich toxins from two cone snail species (Conus textile and Conus stercusmuscarum) and report 13 de novo and about 60 total toxins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.