ArticleCardiovascular diabetology2012
Insulin resistance predicts progression of de novo atherosclerotic plaques in patients with coronary heart disease: a one-year follow-up study.
Article in Cardiovascular diabetology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Relationship between advanced glycation end products and plaque progression in patients with acute coronary syndrome: the JAPAN-ACS sub-study.Cardiovascular diabetology · 2013Trial
- Association of insulin resistance and positive coronary artery remodeling and plaque burden in patients with acute coronary syndrome.BMC cardiovascular disorders · 2026Article
- Triglyceride glucose index-body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states.Diabetology & metabolic syndrome · 2025Article
- Fasting glucagon as an independent risk indicator for CAD in patient with type 2 diabetes.Frontiers in endocrinology · 2025Article
- Associations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes.Cardiovascular diabetology · 2024Article
- Could the Triglyceride-Glucose Index Be a Predictor in the Diagnosis of Coronary Ectasia?Journal of clinical practice and research · 2024Article
- Association between different insulin resistance surrogates and all-cause mortality in patients with coronary heart disease and hypertension: NHANES longitudinal cohort study.Cardiovascular diabetology · 2024Article
- The Role of Insulin Resistance in the Development of Complications after Coronary Artery Bypass Grafting in Patients with Coronary Artery Disease.Biomedicines · 2023Article
- Non-insulin-based insulin resistance indexes in predicting severity for coronary artery disease.Diabetology & metabolic syndrome · 2022Article
- Association between Triglycerides to High-Density Lipoprotein Cholesterol Ratio and Death Risk in Diabetic Patients with New-Onset Acute Coronary Syndrome: A Retrospective Cohort Study in the Han Chinese Population.Reviews in cardiovascular medicine · 2022Article
- Association Between Triglyceride-Glucose Index and 2-Year Adverse Cardiovascular and Cerebrovascular Events in Patients with Type 2 Diabetes Mellitus Who Underwent Off-Pump Coronary Artery Bypass Grafting.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Predictive scores for identifying patients with type 2 diabetes mellitus at risk of acute myocardial infarction and sudden cardiac death.Endocrinology, diabetes & metabolism · 2021Article
- Gestational Diabetes History and Glucose Tolerance After Pregnancy Associated With Coronary Artery Calcium in Women During Midlife: The CARDIA Study.Circulation · 2021Article
- A high triglyceride-glucose index is associated with left ventricular dysfunction and atherosclerosis.International journal of medical sciences · 2021Observational
- Predictive Value of the Triglyceride to High-Density Lipoprotein Cholesterol Ratio for All-Cause Mortality and Cardiovascular Death in Diabetic Patients With Coronary Artery Disease Treated With Statins.Frontiers in cardiovascular medicine · 2021Article
- Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome.Cardiovascular diabetology · 2020Observational
- Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Comparison of the Effects of Fasting Glucose, Hemoglobin ANutrients · 2019Observational
- Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes.Scientific reports · 2019Article
- Serum Triglyceride Lipase Concentrations are Independent Risk Factors for Coronary Artery Disease and In-Stent Restenosis.Journal of atherosclerosis and thrombosis · 2019Article
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7 authors.
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Abstract
backgroundThe aim of our study was to explore and evaluate the relationship between insulin resistance and progression of coronary atherosclerotic plaques. With the great burden coronary heart disease is imposing on individuals, healthcare professionals have already embarked on determining its potential modifiable risk factors in the light of preventive medicine. Insulin resistance has been generally recognized as a novel risk factor based on epidemiological studies; however, few researches have focused on its effect on coronary atherosclerotic plaque progression.
methodsFrom June 7, 2007 to December 30, 2011, 366 patients received their index coronary angiogram and were subsequently found to have coronary atherosclerotic plaques or normal angiograms were consecutively enrolled in the study by the department of cardiology at the Ruijin Hospital, which is affiliated to the Shanghai Jiaotong University School of Medicine. All patients had follow-up angiograms after the 1-year period for evaluating the progression of the coronary lesions. The modified Gensini score was adopted for assessing coronary lesions while the HOMA-IR method was utilized for determining the state of their insulin resistance. Baseline characteristics and laboratory test results were described and the binomial regression analysis was conducted to investigate the relationship between insulin resistance and coronary atherosclerotic plaque progression.
resultsIndex and follow-up Gensini scores were similar between the higher insulin lower insulin resistant groups (9.09 ± 14.33 vs 9.44 ± 12.88, p = 0.813 and 17.21 ± 18.46 vs 14.09 ± 14.18, p =0.358). However the Gensini score assessing coronary lesion progression between both visits was significantly elevated in the higher insulin resistant group (8.13 ± 11.83 versus 4.65 ± 7.58, p = 0.019). Multivariate logistic binomial regression analysis revealed that insulin resistance (HOMA-IR > 3.4583) was an independent predictor for coronary arterial plaque progression (OR = 4.969, p = 0.011). We also divided all the participants into a diabetic (n = 136) and a non-diabetic group (n = 230), and HOMA-IR remained an independent predictor for atherosclerosis plaque progression.
conclusionsInsulin resistance is an independent predictor of atherosclerosis plaque progression in patients with coronary heart disease in both the diabetic and non-diabetic population.
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