ReviewEssays in biochemistry2012
Lysine post-translational modifications and the cytoskeleton.
Review in Essays in biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Evolutionary perspective on mammalian inorganic polyphosphate (polyP) biology.Biochemical Society transactions · 2023Review
- A secreted sirtuin fromScience advances · 2023Article
- PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining.Genome instability & disease · 2023Article
- CHARMM-GUI PDB Manipulator: Various PDB Structural Modifications for Biomolecular Modeling and Simulation.Journal of molecular biology · 2023Article
- The cardioprotective role of sirtuins is mediated in part by regulating KAmerican journal of physiology. Cell physiology · 2023Article
- Proteomic profiling of lysine acetylation and succinylation in Staphylococcus aureus.Clinical and translational medicine · 2022Article
- Development and validation of a novel ubiquitination-related gene prognostic signature based on tumor microenvironment for colon cancer.Translational cancer research · 2022Article
- The role of altered protein acetylation in neurodegenerative disease.Frontiers in aging neuroscience · 2022Review
- Characterization and identification of lysine glutarylation based on intrinsic interdependence between positions in the substrate sites.BMC bioinformatics · 2019Article
- KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2.Clinical epigenetics · 2018Article
- Acetylated Microtubules Are Preferentially Bundled Leading to Enhanced Kinesin-1 Motility.Biophysical journal · 2017Article
- Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.ACS chemical biology · 2017Article
- Temporal Regulation of themSystems · 2016Article
- Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.Protein science : a publication of the Protein Society · 2015Article
- In silico analysis of protein Lys-N(𝜀)-acetylation in plants.Frontiers in plant science · 2014Review
- Networking galore: intermediate filaments and cell migration.Current opinion in cell biology · 2013Review
- Exploring the possible role of lysine acetylation on Entamoeba histolytica virulence: a focus on the dynamics of the actin cytoskeleton.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
PTMs (post-translational modifications) of lysine residues have proven to be major regulators of gene expression, protein-protein interactions, and protein processing and degradation. This is of particular importance in regulating the cytoskeleton, an enormously complex system of proteins responsible for cell motility, intracellular trafficking, and maintenance of cell form and structure. The cytoskeleton is present in all cells, including eukaryotes and prokaryotes, and comprises structures such as flagella, cilia and lamellipodia which play critical roles in intracellular transport and cellular division. Cytoskeletal regulation relies on numerous multi-component assemblies. In this chapter, we focus on the regulation of the cytoskeleton by means of PTMs of lysine residues on the cytoskeletal subunits and their accessory proteins. We specifically address the three main classes of cytoskeletal proteins in eukaryotes that polymerize into filaments, including microfilaments (actin filaments), intermediate filaments and microtubules. We discuss the identification and biological importance of lysine acetylation, a regulator of all three filament types. We also review additional lysine modifications, such as ubiquitination and SUMOylation, and their role in protein regulation and processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.