ArticleMediterranean journal of hematology and infectious diseases2012
Hypophosphatemic Osteomalacia Associated with Tenofovir: a Multidisciplinary Approach is Required.
Article in Mediterranean journal of hematology and infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Tenofovir-induced Fanconi syndrome: a case report and literature review.Oxford medical case reports · 2026Article
- Subtrochanteric Pathological Femur Fracture in an HIV-Positive Patient on Tenofovir-based antiretroviral therapy: A Case Report and Review of the Literature.Journal of orthopaedic case reports · 2023Article
- Incapacitating pain from Tenofovir Induced Hypophosphatemic Osteomalacia in a Hemophilia Patient - A Case Report.Canadian journal of pain = Revue canadienne de la douleur · 2020Article
- Hypophosphatemic osteomalacia induced by tenofovir in HIV-infected patients.Clinical rheumatology · 2016Article
- Corrective osteotomy in femoral non-union in drug-induced hypophosphataemic osteomalacia.BMJ case reports · 2014Article
- Tenofovir as rescue therapy following clinical failure to Lamivudine in severe acute hepatitis B.Mediterranean journal of hematology and infectious diseases · 2013Article
- Article
- Endothelial Nitric Oxide Synthase (eNOS) Gene Polymorphism is Associated with Age Onset of Menarche in Sickle Cell Disease Females of India.Mediterranean journal of hematology and infectious diseases · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We report the case of a 45-year-old woman with chronic HIV infection and personality disorder, who after 12 months of tenofovir, complained of fatigue, diffuse bone pain and gait disturbances. The elevated level of alkaline phosphatase, hypophosphatemia and inappropriate phosphaturia suggested the diagnosis of hypophosphatemic osteomalacia secondary to proximal renal tubulopathy. A dual-energy x-ray absorptiometry showed a bone mineral density below the expected range for age (lumbar spine Z-score -3.3, femoral neck Z-score -2.1). A whole body (99m)Tc-methylene diphosphonate bone scan showed multiple areas of increased focal activity in the lumbar and thoracic spine and in sacroiliac and hip joints consistent with pseudofractures. Two months after tenofovir discontinuation and administration of vitamin D and phosphate, osteomalacia-related symptoms disappeared. Eleven months later, bone and mineral metabolism data were normal and bone scintigraphy did not show any pathological findings.This report highlights the importance of considering the diagnosis of osteomalacia in patients treated with tenofovir and emphasizes the need for monitoring alkaline phosphatase, blood and urinary phosphate and creatinine, especially in patients with risk factors for bone disease.
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