ArticleTranslational stroke research2012
Mixed cerebrovascular disease and the future of stroke prevention.
Article in Translational stroke research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis.Frontiers in neurology · 2022Article
- Cerebral Autoregulation and Neurovascular Coupling in Acute and Chronic Stroke.Frontiers in neurology · 2021Article
- Cerebral Microbleeds in a Stroke Prevention Clinic.Diagnostics (Basel, Switzerland) · 2019Article
- Mixed cerebrovascular disease in an elderly patient with mixed vascular risk factors: a case report.BMC neurology · 2019Article
- Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.Aging and disease · 2018Review
- Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages.Journal of neuroinflammation · 2017Article
- Post-mortem assessment in vascular dementia: advances and aspirations.BMC medicine · 2016Review
- Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice.Critical care medicine · 2016Article
- Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.Microvascular research · 2016Article
- Article
- Definition and Implications of the Preventable Stroke.JAMA neurology · 2016Article
- Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature.Hemodialysis international. International Symposium on Home Hemodialysis · 2015Review
- Treatment of acute cerebral ischemia using animal models: a meta-analysis.Translational neuroscience · 2015Review
- NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage.Annals of neurology · 2014Article
- Protein misfolding and organelle stress after brain ischemia.Translational stroke research · 2013Article
- Review
- MRI screening for chronic anticoagulation in atrial fibrillation.Frontiers in neurology · 2013Review
- Should the STAIR criteria be modified for preconditioning studies?Translational stroke research · 2013Article
- Intracerebral hemorrhage: mechanisms and therapies.Translational stroke research · 2012Article
- The cerebral circulation and cerebrovascular disease III: Stroke.Brain circulationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Stroke prevention efforts typically focus on either ischemic or hemorrhagic stroke. This approach is overly simplistic due to the frequent coexistence of ischemic and hemorrhagic cerebrovascular disease. This coexistence, termed "mixed cerebrovascular disease", offers a conceptual framework that appears useful for stroke prevention strategies. Mixed cerebrovascular disease incorporates clinical and subclinical syndromes, including ischemic stroke, subclinical infarct, white matter disease of aging (leukoaraiosis), intracerebral hemorrhage, and cerebral microbleeds. Reliance on mixed cerebrovascular disease as a diagnostic entity may assist in stratifying risk of hemorrhagic stroke associated with platelet therapy and anticoagulants. Animal models of hemorrhagic cerebrovascular disease, particularly models of cerebral amyloid angiopathy and hypertension, offer novel means for identifying underlying mechanisms and developing focused therapy. Phosphodiesterase (PDE) inhibitors represent a class of agents that, by targeting both platelets and vessel wall, provide the kind of dual actions necessary for stroke prevention, given the spectrum of disorders that characterizes mixed cerebrovascular disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.