ArticleFrontiers in genetics2012
Enhanced genotoxicity of silver nanoparticles in DNA repair deficient Mammalian cells.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 80 citations in OpenAlex.
- Current advances in metal nanoparticle-based stimuli-responsive nanotherapies.Frontiers in chemistry · 2026Review
- Targeted therapy and biomarker-guided applications of ecofriendly silver nanoparticles in precision oncology.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2025Review
- Article
- Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment.Nanomaterials (Basel, Switzerland) · 2022Review
- Incorporation of Low Concentrations of Gold Nanoparticles: Complex Effects on Radiation Response and Fate of Cancer Cells.Pharmaceutics · 2022Article
- Assessment of genotoxicity of silver nanoparticles on lymphocyte cells of albino rats using comet assay.Toxicology research · 2021Article
- The mechanism of cell death induced by silver nanoparticles is distinct from silver cations.Particle and fibre toxicology · 2021Article
- The Action-Networks of Nanosilver: Bridging the Gap between Material and Biology.Advanced healthcare materials · 2021Review
- Antimicrobial Potential of Bioactive Metabolites and Silver Nanoparticles fromTurkish journal of pharmaceutical sciences · 2020Article
- Silver-decorated gel-shell nanobeads: physicochemical characterization and evaluation of antibacterial properties.Beilstein journal of nanotechnology · 2020Article
- Encapsulation of Biosynthesized Nanosilver in Silica Composites for Sustainable Antimicrobial Functionality.Global challenges (Hoboken, NJ) · 2018Article
- Nanoscale wide-band semiconductors for photocatalytic remediation of aquatic pollution.Environmental science and pollution research international · 2017Review
- Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin.Journal of nanomaterials · 2017Article
- Emerging metrology for high-throughput nanomaterial genotoxicology.Mutagenesis · 2017Review
- Cancer cells that survive checkpoint adaptation contain micronuclei that harbor damaged DNA.Cell cycle (Georgetown, Tex.) · 2016Article
- Cytotoxicity of glass ionomer cements containing silver nanoparticles.Journal of clinical and experimental dentistry · 2015Article
- Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity.Mutagenesis · 2015Article
- The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade.Pathology oncology research : POR · 2015Article
- Gene Expression, Protein Function and Pathways ofNanomaterials (Basel, Switzerland) · 2015Article
- Carboxylated short single-walled carbon nanotubes but not plain and multi-walled short carbon nanotubes show in vitro genotoxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silver nanoparticles (Ag-np) have been used in medicine and commercially due to their anti-microbial properties. Therapeutic potentials of these nanoparticles are being explored extensively despite the lack of information on their mechanism of action at molecular and cellular level. Here, we have investigated the DNA damage response and repair following Ag-np treatment in mammalian cells. Studies have shown that Ag-np exerts genotoxicity through double-strand breaks (DSBs). DNA-PKcs, the catalytic subunit of DNA dependent protein kinase, is an important caretaker of the genome which is known to be the main player mediating Non-homologous End-Joining (NHEJ) repair pathway. We hypothesize that DNA-PKcs is responsible for the repair of Ag-np induced DNA damage. In vitro studies have been carried out to investigate both cytotoxicity and genotoxicity induced by Ag-np in normal human cells, DNA-PKcs proficient, and deficient mammalian cells. Chemical inhibition of DNA-PKcs activity with NU7026, an ATP-competitive inhibitor of DNA-PKcs, has been performed to further validate the role of DNA-PKcs in this model. Our results suggest that Ag-np induced more prominent dose-dependent decrease in cell viability in DNA-PKcs deficient or inhibited cells. The deficiency or inhibition of DNA-PKcs renders the cells with higher susceptibility to DNA damage and genome instability which in turn contributed to greater cell cycle arrest/cell death. These findings support the fact that DNA-PKcs is involved in the repair of Ag-np induced genotoxicity and NHEJ repair pathway and DNA-PKcs particularly is activated to safeguard the genome upon Ag-np exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.