ReviewThe Journal of biological chemistry2012
Biological synthesis of circular polypeptides.
Review in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Improving the specific activity and stability of alkaline pectinase PEL3 through SpyTag/SpyCatcher cyclization.Biotechnology letters · 2023Article
- Discovery and Characteristics of a Novel Antitumor Cyclopeptide Derived from Shark.Bioengineering (Basel, Switzerland) · 2023Article
- Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development.Molecules (Basel, Switzerland) · 2022Review
- Peptide/protein-based macrocycles: from biological synthesis to biomedical applications.RSC chemical biology · 2022Review
- Scalable and Efficient In Planta Biosynthesis of Sunflower Trypsin Inhibitor-1 (SFTI) Peptide Therapeutics.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Protein-protein interactions enhance the thermal resilience of SpyRing-cyclized enzymes: A molecular dynamic simulation study.PloS one · 2022Article
- Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases.Pharmaceuticals (Basel, Switzerland) · 2020Article
- The life cycle of cyclotides: biosynthesis and turnover in plant cells.Plant cell reports · 2020Article
- The Potential of the Cyclotide Scaffold for Drug Development.Biomedicines · 2019Review
- Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide.Frontiers in plant science · 2019Article
- In-cell production of a genetically-encoded library based on the θ-defensin RTD-1 using a bacterial expression system.Bioorganic & medicinal chemistry · 2018Article
- Inteins: Localized Distribution, Gene Regulation, and Protein Engineering for Biological Applications.Microorganisms · 2018Review
- Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta.Journal of experimental botany · 2018Article
- Cyclotides: Overview and Biotechnological Applications.Chembiochem : a European journal of chemical biology · 2017Review
- Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency.Scientific reports · 2017Article
- Topology Engineering of ProteinsACS central science · 2017Article
- Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing.Biopolymers · 2016Article
- Enhanced thermal stability of lichenase from Bacillus subtilis 168 by SpyTag/SpyCatcher-mediated spontaneous cyclization.Biotechnology for biofuels · 2016Article
- Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids.ACS chemical biology · 2015Article
- Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain.Frontiers in chemistry · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Here, we review the use of different biochemical approaches for biological synthesis of circular or backbone-cyclized proteins and peptides. These methods allow the production of circular polypeptides either in vitro or in vivo using standard recombinant DNA expression techniques. Protein circularization can significantly impact protein engineering and research in protein folding. Basic polymer theory predicts that circularization should lead to a net thermodynamic stabilization of a folded protein by reducing the entropy associated with the unfolded state. Protein cyclization also provides a valuable tool for exploring the effects of topology on protein folding kinetics. Furthermore, the biological production of cyclic polypeptides makes possible the production of cyclic polypeptide libraries. The generation of such libraries, which was previously restricted to the domain of synthetic chemists, now offers biologists access to highly diverse and stable molecular libraries for probing protein structure and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.