ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2012
Use of fertility drugs and risk of ovarian cancer: results from a U.S.-based case-control study.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Ovulation induction drug and ovarian cancer: an updated systematic review and meta-analysis.Journal of ovarian research · 2023Pooled it
- Age at menarche and epithelial ovarian cancer risk: A meta-analysis and Mendelian randomization study.Cancer medicine · 2019Pooled it
- Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility.The Cochrane database of systematic reviews · 2019Pooled it
- Breastfeeding and maternal health outcomes: a systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2015Pooled it
- Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility.The Cochrane database of systematic reviews · 2013Pooled it
- Review
- Infertility and risk of ovarian cancer: A systematic review and meta analysis.Journal of family medicine and primary care · 2025Review
- Systematic review of the association between talc and female reproductive tract cancers.Frontiers in toxicology · 2023Review
- Talc, body powder, and ovarian cancer: A summary of the epidemiologic evidence.Gynecologic oncology · 2021Review
- Association Between Breastfeeding and Ovarian Cancer Risk.JAMA oncology · 2020Article
- Data on systematic review and meta-analysis of epidemiologic evidence on the association between perineal use of talc powder and risk of ovarian cancer.Data in brief · 2020Article
- Ovarian cancer stem cells and targeted therapy.Journal of ovarian research · 2019Review
- Talc, Asbestos, and Epidemiology: Corporate Influence and Scientific Incognizance.Epidemiology (Cambridge, Mass.) · 2019Article
- The risk of breast and gynecological cancer in women with a diagnosis of infertility: a nationwide population-based study.European journal of epidemiology · 2019Article
- Association of Combined Estrogen-Progestogen and Progestogen-Only Contraceptives with the Development of Cancer.The Linacre quarterly · 2018Review
- Prognosis and conditional disease-free survival among patients with ovarian cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Use of fertility drugs and risk of ovarian cancer.Current opinion in obstetrics & gynecology · 2014Review
- LINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients.Gynecologic oncology · 2014Article
- A Case of Malignant Pheochromocytoma Detected during Fertility Treatment.Case reports in urology · 2014Article
- Ovulation-inducing drugs and ovarian cancer risk: results from an extended follow-up of a large United States infertility cohort.Fertility and sterility · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundPrevious studies examining associations between use of fertility drugs and ovarian cancer risk have provided conflicting results. We used data from a large case-control study to determine whether fertility drug use significantly impacts ovarian cancer risk when taking into account parity, gravidity, and cause of infertility.
methodsData from the Hormones and Ovarian Cancer Prediction (HOPE) study were used (902 cases, 1,802 controls). Medical and reproductive histories were collected via in-person interviews. Logistic regression was used to calculate ORs and 95% confidence intervals (CI). Models were adjusted for age, race, education, age at menarche, parity, oral contraceptive use, breastfeeding, talc use, tubal ligation, and family history of breast/ovarian cancer.
resultsEver use of fertility drugs was not significantly associated with ovarian cancer within the total HOPE population (OR, 0.93; 95% CI, 0.65-1.35) or among women who reported seeking medical attention for infertility (OR, 0.87; 95% CI, 0.54-1.40). We did observe a statistically significant increased risk of ovarian cancer for ever use of fertility drugs among women who, despite seeking medical attention for problems getting pregnant, remained nulligravid (OR, 3.13; 95% CI, 1.01-9.67).
conclusionsThese results provide further evidence that fertility drug use does not significantly contribute to ovarian cancer risk among the majority of women; however, women who despite infertility evaluation and fertility drug use remain nulligravid, may have an elevated risk for ovarian cancer. IMPACT: Our results suggest that fertility drug use does not significantly contribute to overall risk of ovarian cancer when adjusting for known confounding factors.
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