Evidence map›Paper›PMID 22707253›Full record

Trial reportPsychopharmacology2012

Testosterone induces off-line perceptual learning.

Nicholas D Wright, Thomas Edwards, Stephen M Fleming, Raymond J Dolan

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Nicholas D WrightWellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK. n.wright@ucl.ac.uk
Thomas Edwards
Stephen M Fleming
Raymond J Dolan
Wellcome Centre for Human Neuroimaging · GBNational Hospital for Neurology and Neurosurgery · GBNew York University · US

Funding

Wellcome Trust 078865/Z/05/ZWellcome Trust 091593Wellcome Trust 091593/Z/10/ZWellcome Trust 098362
6 · The paper itself

Abstract

rationalePerceptual learning operates on distinct timescales. How different neuromodulatory systems impact on learning across these different timescales is poorly understood.

objectivesHere, we test the causal impact of a novel influence on perceptual learning, the androgen hormone testosterone, across distinct timescales.

methodsIn a double-blind, placebo- controlled, cross-over study with testosterone, subjects undertook a simple contrast detection task during training sessions on two separate days.

resultsOn placebo, there was no learning either within training sessions or between days, except for a fast, rapidly saturating, improvement early on each testing day. However, testosterone caused "off-line" learning, with no learning seen within training sessions, but a marked performance improvement over the days between sessions. This testosterone-induced learning occurred in the absence of changes in subjective confidence or introspective accuracy.

conclusionsOur findings show that testosterone influences perceptual learning on a timescale consistent with an influence on "off-line" consolidation processes.

Indexed as

AdultAnalysis of VarianceContrast SensitivityCross-Over StudiesDouble-Blind MethodFemaleHumansLearningNeuropsychological TestsPhotic StimulationTestosteroneTime FactorsYoung AdultTestosterone

Identifiers

PMID22707253
PMCPMC3496538
OpenAlexW2148694415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.