Trial reportPsychopharmacology2012
Effects of acute nicotine on auditory change-related cortical responses.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study.Brain topography · 2022Article
- Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers.European journal of pain (London, England) · 2022Article
- Relationship of loudness-dependent auditory evoked potentials with change-related cortical responses.PloS one · 2022Article
- Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study.Life (Basel, Switzerland) · 2021Article
- Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli.Brain topography · 2019Article
- Effects of Sound-Pressure Change on the 40 Hz Auditory Steady-State Response and Change-Related Cerebral Response.Brain sciences · 2019Article
- Change-Related Acceleration Effects on Auditory Steady State Response.Frontiers in systems neuroscience · 2019Article
- Long-latency suppression of auditory and somatosensory change-related cortical responses.PloS one · 2018Article
- GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans.PloS one · 2018Article
- New paradigm for auditory paired pulse suppression.PloS one · 2017Article
- Inhibition in the Human Auditory Cortex.PloS one · 2016Article
- Prepulse inhibition of auditory change-related cortical responses.BMC neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE AND
objectiveNicotine is known to have enhancing effects on some aspects of attention and cognition. The purpose of the present study was to elucidate the effects of nicotine on pre-attentive change-related cortical activity.
methodsChange-related cortical activity in response to an abrupt increase (3 dB) and decrease (6 dB) in sound pressure in a continuous sound was recorded by using magnetoencephalography. Nicotine was administered with a nicotine gum (4 mg of nicotine). Eleven healthy nonsmokers were tested with a double-blind and placebo-controlled design. Effects of nicotine on the main component of the onset response peaking at around 50 ms (P50m) and the main component of the change-related response at around 120 ms (Change-N1m) were investigated.
resultsNicotine failed to affect P50m, while it significantly increased the amplitude of Change-N1m evoked by both auditory changes. The magnitude of the amplitude increase was similar among subjects regardless of the magnitude of the baseline response, which resulted in the percent increase of Change-N1m being greater for subjects with Change-N1m of smaller amplitude.
conclusionsSince Change-N1m represents a pre-attentive automatic process to encode new auditory events, the present results suggest that nicotine can exert beneficial cognitive effects without a direct impact on attention.
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