ReviewInternational urogynecology journal2013
Bulking agents: an analysis of 500 cases and review of the literature.
Review in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Adverse Events Associated with Nonsurgical Treatments for Urinary Incontinence in Women: a Systematic Review.Journal of general internal medicine · 2019Pooled it
- Intraurethral bulking agents for the management of female stress urinary incontinence: a systematic review.International urogynecology journal · 2017Pooled it
- Polyacrylamide hydrogel (Bulkamid®) for stress urinary incontinence in women: a systematic review of the literature.International urogynecology journal · 2016Pooled it
- Quality of life and sexual function after TVT surgery versus Bulkamid injection for primary stress urinary incontinence: 1 year results from a randomized clinical trial.International urogynecology journal · 2021Trial
- Failure Rate, Time to Failure, and Associated Risk Factors: Polyacrylamide Hydrogel Injection for the Treatment of Stress Urinary Incontinence in a Large Cohort.International urogynecology journal · 2026Article
- Prevalence of urinary incontinence in postpartum women and physiotherapy interventions applied: An integrative review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Urethral bulking agents: a retrospective review of primary versus salvage procedure outcomes.World journal of urology · 2021Article
- Contemporary diagnostics and treatment options for female stress urinary incontinence.Asian journal of urology · 2018Review
- Bulkamid (PAHG) in mixed urinary incontinence: What is the outcome?International urogynecology journal · 2017Article
- Effects of laser procedure for female urodynamic stress incontinence on pad weight, urodynamics, and sexual function.International urogynecology journal · 2017Article
- Treatment of stress urinary incontinence using polyacrylamide hydrogel in women after radiotherapy: 1-year follow-up.International urogynecology journal · 2016Article
- Collagenoma and voiding dysfunction as complications of periurethral bulking.International urogynecology journal · 2015Article
- Urolastic for the treatment of women with stress urinary incontinence: 24-month follow-up.Central European journal of urology · 2015Article
- The surgical trends and time-frame comparison of primary surgery for stress urinary incontinence, 2006-2010 vs 1997-2005: a population-based nation-wide follow-up descriptive study.International urogynecology journal · 2014Article
- Use of symptom-relieving drugs before and after surgery for urinary incontinence in women: a cohort study.BMJ open · 2013Article
- Urolastic-a new bulking agent for the treatment of women with stress urinary incontinence: outcome of 12 months follow up.Advances in urology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisStress urinary incontinence (SUI) is common, impacts women's quality of life, and generates high costs. Physiotherapy is the first-line therapy, and if it fails, suburethral slings are the gold standard in SUI surgery. Bulking agents injected periurethrally might be a beneficial alternative, but there is a paucity of data on bulking therapy. The aim of this study was to prospectively analyze the efficacy and safety of bulking agents in the setting of a tertiary referral center.
methodsIn the last 13 years, 514 elderly women with SUI were treated by injection therapy with either collagen (Contigen), hyaluronic acid (Zuidex), ethylene vinyl alcohol (Tegress), or polyacrylamide hydrogel (Bulkamid). Subjective and objective outcome was recorded at the 12-month postoperative appointment using the King's Health Questionnaire, visual analogue scale (VAS) describing their incontinence severity, standardized pad test, and urethral pressure profile.
resultsDemographic data were equally distributed in all four groups of agents used. Sixty-one patients were lost to follow-up (10.6 %). Statistically significant changes were found for maximum urethral closure pressure (MUCP), pad weight, and VAS before and after bulking for the four agents used. Pad test was negative in 73.2 % of patients after bulking therapy. Subjective assessment showed improvements in general health and role limitations. The overall complication rate was low for all agents.
conclusionsThis study shows improvement in incontinence after bulking therapy according to subjective and objective outcomes in an elderly population. In contrast to earlier reports, side effects due to injections were few and mild. We can advocate bulking therapy for treating SUI, as it is simple, safe, and shows both objective and subjective improvement and relief.
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