ArticleApplied and environmental microbiology2012
Identification and characterization of Cronobacter iron acquisition systems.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Functional characterization of iucC and iucD in iron acquisition and virulence of Cronobacter sakazakii.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Development and Application of a Species-Specific PCR Assay for the Detection of the Emerging Food-Borne Pathogen Cronobacter Sakazakii.Current microbiology · 2025Article
- Single-cell phenotyping of extracellular electron transfer via microdroplet encapsulation.Applied and environmental microbiology · 2025Article
- Characterization ofFrontiers in microbiology · 2025Article
- Single-Cell Phenotyping of Extracellular Electron Transfer via Microdroplet Encapsulation.bioRxiv : the preprint server for biology · 2024Article
- Comprehensive Genomic Characterization ofMicroorganisms · 2023Article
- Alterations in the Transcriptional Landscape Allow Differential Desiccation Tolerance in Clinical Cronobacter sakazakii.Applied and environmental microbiology · 2021Article
- Occurrence, Virulence and Antimicrobial Susceptibility Profiles of Cronobacter spp. from Ready-to-Eat Foods.Current microbiology · 2021Article
- The Secretion of Toxins and Other Exoproteins ofMicroorganisms · 2020Review
- Putative Iron Acquisition Systems inMolecules (Basel, Switzerland) · 2018Article
- Reconstituting the History of Cronobacter Evolution Driven by Differentiated CRISPR Activity.Applied and environmental microbiology · 2018Article
- Virulence and Antibiotic Resistance Profiles ofFrontiers in microbiology · 2018Article
- Modified microplate method for rapid and efficient estimation of siderophore produced by bacteria.3 Biotech · 2017Article
- Comparative genomic analysis and characterization of incompatibility group FIB plasmid encoded virulence factors of Salmonella enterica isolated from food sources.BMC genomics · 2017Article
- DNA-Sequence Based Typing of theFrontiers in microbiology · 2017Article
- A Negative Regulator of Cellulose Biosynthesis,Frontiers in microbiology · 2017Article
- Comparative study of Cronobacter identification according to phenotyping methods.BMC microbiology · 2016Article
- Hfq plays important roles in virulence and stress adaptation in Cronobacter sakazakii ATCC 29544.Infection and immunity · 2015Article
- Novel approaches to improve the intrinsic microbiological safety of powdered infant milk formula.Nutrients · 2015Review
- Insights into virulence factors determining the pathogenicity of Cronobacter sakazakii.Virulence · 2015Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Cronobacter spp. are emerging pathogens that cause severe infantile meningitis, septicemia, or necrotizing enterocolitis. Contaminated powdered infant formula has been implicated as the source of Cronobacter spp. in most cases, but questions still remain regarding the natural habitat and virulence potential for each strain. The iron acquisition systems in 231 Cronobacter strains isolated from different sources were identified and characterized. All Cronobacter spp. have both the Feo and Efe systems for acquisition of ferrous iron, and all plasmid-harboring strains (98%) have the aerobactin-like siderophore, cronobactin, for transport of ferric iron. All Cronobacter spp. have the genes encoding an enterobactin-like siderophore, although it was not functional under the conditions tested. Furthermore, all Cronobacter spp. have genes encoding five receptors for heterologous siderophores. A ferric dicitrate transport system (fec system) is encoded specifically by a subset of Cronobacter sakazakii and C. malonaticus strains, of which a high percentage were isolated from clinical samples. Phylogenetic analysis confirmed that the fec system is most closely related to orthologous genes present in human-pathogenic bacterial strains. Moreover, all strains of C. dublinensis and C. muytjensii encode two receptors, FcuA and Fct, for heterologous siderophores produced by plant pathogens. Identification of putative Fur boxes and expression of the genes under iron-depleted conditions revealed which genes and operons are components of the Fur regulon. Taken together, these results support the proposition that C. sakazakii and C. malonaticus may be more associated with the human host and C. dublinensis and C. muytjensii with plants.
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