ArticleEpigenetics2012
Global DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry.
Article in Epigenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Blood-based DNA methylation as biomarker for breast cancer: a systematic review.Clinical epigenetics · 2016Pooled it
- Trial
- Can DNA Methylation in Peritumoral and Contralateral Breast Tissue Predict Recurrence or Second Breast Cancers?Current issues in molecular biology · 2026Article
- Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer.Epigenetics & chromatin · 2023Article
- DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women.Basic & clinical pharmacology & toxicology · 2020Article
- DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study.Reproductive toxicology (Elmsford, N.Y.) · 2020Article
- DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer.Clinical epigenetics · 2019Article
- White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO).Breast cancer research : BCR · 2017Article
- Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors.Journal of cancer epidemiology · 2017Review
- Mismatch Repair Polymorphisms as Markers of Breast Cancer Prevalence in the Breast Cancer Family Registry.Anticancer research · 2016Article
- Cohort Profile: The Breast Cancer Prospective Family Study Cohort (ProF-SC).International journal of epidemiology · 2016Article
- Epigenetic Biomarkers of Breast Cancer Risk: Across the Breast Cancer Prevention Continuum.Advances in experimental medicine and biology · 2016Review
- DNA methylation as a promising landscape: A simple blood test for breast cancer prediction.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Article
- Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.Future oncology (London, England) · 2015Article
- Mutation screening of PALB2 in clinically ascertained families from the Breast Cancer Family Registry.Breast cancer research and treatment · 2015Article
- The impact of cancer prevention guideline adherence on overall mortality in a high-risk cohort of women from the New York site of the Breast Cancer Family Registry.Breast cancer research and treatment · 2015Article
- Global DNA Methylation, Measured by the Luminometric Methylation Assay (LUMA), Associates with Postmenopausal Breast Cancer in Non-Obese and Physically Active Women.Journal of Cancer · 2015Article
- Correlations in global DNA methylation measures in peripheral blood mononuclear cells and granulocytes.Epigenetics · 2014Article
- Correlation of DNA methylation levels in blood and saliva DNA in young girls of the LEGACY Girls study.Epigenetics · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Lower global DNA methylation is associated with genomic instability and it is one of the epigenetic mechanisms relevant to carcinogenesis. Emerging evidence for several cancers suggests that lower overall levels of global DNA methylation in blood are associated with different cancer types, although less is known about breast cancer. We examined global DNA methylation levels using a sibling design in 273 sisters affected with breast cancer and 335 unaffected sisters from the New York site of the Breast Cancer Family Registry. We measured global DNA methylation in total white blood cell (WBC) and granulocyte DNA by two different methods, the [ ( 3) H]-methyl acceptance assay and the luminometric methylation assay (LUMA). Global methylation levels were only modestly correlated between sisters discordant for breast cancer (Spearman correlation coefficients ranged from -0.08 to 0.24 depending on assay and DNA source). Using conditional logistic regression models, women in the quartile with the lowest DNA methylation levels (as measured by the [ ( 3) H]-methyl acceptance assay) had a 1.8-fold (95% CI = 1.0-3.3) higher relative association with breast cancer than women in the quartile with the highest DNA methylation levels. When we examined the association on a continuous scale, we also observed a positive association (odds ratio, OR = 1.3, 95% CI = 1.0-1.7, for a one unit change in the natural logarithm of the DPM/μg of DNA). We observed no association between measures by the LUMA assay and breast cancer risk. If replicated in prospective studies, this study suggests that global DNA methylation levels measured in WBC may be a potential biomarker of breast cancer risk even within families at higher risk of cancer.
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