ReviewBiochimica et biophysica acta2013
Signal transduction pathways, intrinsic regulators, and the control of cell fate choice.
Review in Biochimica et biophysica acta, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis.PLoS genetics · 2021Article
- The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis.Development (Cambridge, England) · 2020Article
- Persistent symbiont colonization leads to a maturation of hemocyte response in the Euprymna scolopes/Vibrio fischeri symbiosis.MicrobiologyOpen · 2019Article
- Article
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila.Developmental biology · 2018Article
- Pancreatic cancer stem cell markers and exosomes - the incentive push.World journal of gastroenterology · 2016Review
- Adaptive homeostasis.Molecular aspects of medicine · 2016Review
- Two Independent Functions of Collier/Early B Cell Factor in the Control of Drosophila Blood Cell Homeostasis.PloS one · 2016Article
- Article
- Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice.Journal of biomedical science · 2015Article
- The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.Molecular cancer · 2014Review
- Harnessing the naturalCurrent opinion in insect science · 2014Article
- An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila.Genetics · 2014Article
- Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation.PloS one · 2014Article
- Achieving peptide binding specificity and promiscuity by loops: case of the forkhead-associated domain.PloS one · 2014Article
- Drosophila E-cadherin functions in hematopoietic progenitors to maintain multipotency and block differentiation.PloS one · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
backgroundInformation regarding changes in organismal status is transmitted to the stem cell regulatory machinery by a limited number of signal transduction pathways. Consequently, these pathways derive their functional specificity through interactions with stem cell intrinsic master regulators, notably transcription factors. Identifying the molecular underpinnings of these interactions is critical to understanding stem cell function. SCOPE OF REVIEW: This review focuses on studies in Drosophila that identify the gene regulatory basis for interactions between three different signal transduction pathways and an intrinsic master transcriptional regulator in the context of hematopoietic stem-like cell fate choice. Specifically, the interface between the GATA:FOG regulatory complex and the JAK/STAT, BMP, and Hedgehog pathways is examined. MAJOR
conclusionsThe GATA:FOG complex coordinates information transmitted by at least three different signal transduction pathways as a means to control stem-like cell fate choice. This illustrates emerging principles concerning regulation of stem cell function and describes a gene regulatory link between changes in organismal status and stem cell response. GENERAL SIGNIFICANCE: The Drosophila model system offers a powerful approach to identify the molecular basis of how stem cells receive, interpret, and then respond to changes in organismal status. This article is part of a Special Issue entitled: Biochemistry of Stem Cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.