ArticleCell death and differentiation2012
The TNF family member APRIL promotes colorectal tumorigenesis.
Article in Cell death and differentiation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- CCN1 promotes APRIL/BAFF signaling in esophageal squamous cell carcinoma but attenuates it in esophageal adenocarcinoma.Scientific reports · 2025Article
- Potential Utility of A Proliferation-Inducing Ligand (APRIL) in Colorectal Cancer.International journal of molecular sciences · 2024Review
- The BAFF-APRIL System in Cancer.Cancers · 2023Review
- Binary MoSMikrochimica acta · 2022Article
- Upregulation of microRNA-383 inhibits the proliferation, migration and invasion of colon cancer cells.Oncology letters · 2018Article
- APRIL, BCMA and TACI proteins are abnormally expressed in non-small cell lung cancer.Oncology letters · 2016Article
- Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.Oncotarget · 2015Article
- Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients.Oncogenesis · 2015Article
- Identification of the sAPRIL binding peptide and its growth inhibition effects in the colorectal cancer cells.PloS one · 2015Article
- Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.The EMBO journal · 2014Article
- Amelioration of colorectal cancer using negative lipidoid nanoparticles to encapsulate siRNA against APRIL by enema delivery mode.Pathology oncology research : POR · 2014Article
- Article
- APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-β1/ERK signaling pathway in human colorectal cancer cells.Molecular and cellular biochemistry · 2013Article
- APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway.PloS one · 2013Article
- The design and characterization of receptor-selective APRIL variants.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor necrosis factor (TNF) family member APRIL (A proliferation inducing ligand) is a disease promoter in B-cell malignancies. APRIL has also been associated with a wide range of solid malignancies, including colorectal cancer (CRC). As evidence for a supportive role of APRIL in solid tumor formation was still lacking, we studied the involvement of APRIL in CRC. We observed that ectopic APRIL expression exacerbates the number and size of adenomas in Apc(Min) mice and in a mouse model for colitis-associated colon carcinogenesis. Furthermore, knockdown of APRIL in primary spheroid cultures of colon cancer cells and both mouse and human CRC cell lines reduced tumor clonogenicity and in vivo outgrowth. Taken together, our data therefore indicate that both tumor-derived APRIL and APRIL produced by non-tumor cells is supportive in colorectal tumorigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.