ArticleNucleic acids research2012
CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales.Nucleic acids research · 2025Article
- STAT3 and SOX-5 induce BRG1-mediated chromatin remodeling of RORCE2 in Th17 cells.Communications biology · 2024Article
- Uncovering the Principles of Genome Folding by 3D Chromatin Modeling.Cold Spring Harbor perspectives in biology · 2022Review
- SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation.Nature communications · 2021Article
- Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis.Nucleic acids research · 2020Article
- Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data.Methods (San Diego, Calif.) · 2020Review
- The Functional 3D Organization of Unicellular Genomes.Scientific reports · 2019Article
- Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system.Nucleic acids research · 2019Article
- Producing genome structure populations with the dynamic and automated PGS software.Nature protocols · 2018Article
- Evolution of hemoglobin loci and their regulatory elements.Blood cells, molecules & diseases · 2018Review
- Computational construction of 3D chromatin ensembles and prediction of functional interactions of alpha-globin locus from 5C data.Nucleic acids research · 2017Article
- Article
- The three-dimensional genome organization of Drosophila melanogaster through data integration.Genome biology · 2017Article
- Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding.Molecular and cellular biology · 2017Article
- Article
- Long-range looping of a locus control region drives tissue-specific chromatin packing within a multigene cluster.Nucleic acids research · 2016Article
- Predicting the three-dimensional folding of cis-regulatory regions in mammalian genomes using bioinformatic data and polymer models.Genome biology · 2016Article
- Population-based 3D genome structure analysis reveals driving forces in spatial genome organization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- 3CPET: finding co-factor complexes from ChIA-PET data using a hierarchical Dirichlet process.Genome biology · 2015Article
- An Overview of Genome Organization and How We Got There: from FISH to Hi-C.Microbiology and molecular biology reviews : MMBR · 2015Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mammalian gene regulation. We investigated the three-dimensional folding of a 1 Mbp region of human chromosome 11 containing the β-globin genes by integrating looping interactions of the CCCTC-binding insulator protein CTCF determined comprehensively by chromosome conformation capture (3C) into a polymer model of chromatin. We find that CTCF-mediated cell type-specific interactions in erythroid cells are organized to favor contacts known to occur in vivo between the β-globin locus control region (LCR) and genes. In these cells, the modeled β-globin domain folds into a globule with the LCR and the active globin genes on the periphery. In contrast, in non-erythroid cells, the globule is less compact with few but dominant CTCF interactions driving the genes away from the LCR. This leads to a decrease in contact frequencies that can exceed 1000-fold depending on the stiffness of the chromatin and the exact position of the genes. Our findings show that an ensemble of CTCF contacts functionally affects spatial distances between control elements and target genes contributing to chromosomal organization required for transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.