ArticleJournal of veterinary science2012
The role of inflammation and matrix metalloproteinases in equine endometriosis.
Article in Journal of veterinary science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Amniotic Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles for Equine Chronic Degenerative Endometritis Treatment.Veterinary medicine and science · 2026Article
- Exploring the role of epigenetics in the processes related to the development of endometrosis in the mare.The Journal of reproduction and development · 2026Review
- Bidirectional Interaction Between PGEProteomes · 2025Article
- Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential.Animals : an open access journal from MDPI · 2025Review
- Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options.Animals : an open access journal from MDPI · 2024Review
- Prostaglandin pathways in equine myometrium regulations: endometrosis progression.Frontiers in veterinary science · 2024Article
- Collagen Type III as a Possible Blood Biomarker of Fibrosis in Equine Endometrium.Animals : an open access journal from MDPI · 2022Article
- The NF-κB-signalling pathway in mare's endometrium infiltrated with the inflammatory cells.Reproduction in domestic animals = Zuchthygiene · 2022Article
- Evolution of the Concepts of Endometrosis, Post Breeding Endometritis, and Susceptibility of Mares.Animals : an open access journal from MDPI · 2022Review
- Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis.Frontiers in veterinary science · 2022Article
- Metformin Alleviates Endometriosis and Potentiates Endometrial ReceptivityFrontiers in pharmacology · 2022Article
- Myeloperoxidase Inhibition Decreases the Expression of Collagen and Metallopeptidase in Mare Endometria under In Vitro Conditions.Animals : an open access journal from MDPI · 2021Article
- Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis.Scientific reports · 2020Article
- The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare.Frontiers in veterinary science · 2020Article
- Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season.BMC veterinary research · 2019Article
- Article
- Correlation between matrix metalloproteinase-9 and endometriosis.International journal of clinical and experimental pathology · 2015Article
- Immunomodulatory Role of Adipose-Derived Stem Cells on Equine Endometriosis.BioMed research international · 2015Article
- CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.Reproductive biology and endocrinology : RB&E · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Equine endometriosis is a multifactorial disease considered to be a major cause of equine infertility. The purpose of this study was to evaluate the reliability of histomorphological grading for biopsy-like samples compared to entire uterine wall samples, to examine the association between the degree of endometriosis with animal age, and to investigate the role of inflammation in endometriosis and the expression of different matrix metalloproteinases in equine endometrium. Histomorphological lesions in 35 uterine samples were examined while comparing biopsy-like samples and entire-wall samples. Seventeen uterine samples were stained with antibodies against MMP-2, MMP-9, MMP-14, and TIMP-2. The morphologic evaluation results of the biopsy-like tissue and entire-wall samples were significantly correlated. Endometriosis in older mares (>12 years of age) was more severe than in young mares (2 ~ 4 years of age), confirming the positive correlation between animal age and disease severity, while inflammation was poorly related to the degree of endometriosis. MMP-2 and MMP-14 were detected in stromal cells, while MMP-9 and TIMP-2 were both found in stromal and glandular epithelial cells. There were no significant differences in MMPs expression between the two groups (young vs. old mares). Additional studies on the activity of MMPs could further define the role of these enzymes in equine endometriosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.