ArticleActa pharmacologica Sinica2012
Excess genistein suppresses the synthesis of extracellular matrix in female rat mandibular condylar cartilage.
Article in Acta pharmacologica Sinica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation.Nutrients · 2019Article
- Phytoestrogen (Daidzein) Promotes Chondrogenic Phenotype of Human Chondrocytes in 2D and 3D Culture Systems.Tissue engineering and regenerative medicine · 2017Article
- Genistein treatment improves fracture resistance in obese diabetic mice.BMC endocrine disorders · 2017Article
- Genistein treatment increases bone mass in obese, hyperglycemic mice.Diabetes, metabolic syndrome and obesity : targets and therapy · 2016Article
- Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential.Steroids · 2014Review
- Selective ligands of estrogen receptor β discovered using pharmacophore mapping and structure-based virtual screening.Acta pharmacologica Sinica · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effect of excess genistein on the extracellular matrix in mandibular condylar cartilage of female rats in vivo.
methodsFemale SD rats were administered through oral gavage with genistein (50 mg/kg) or placebo daily for 6 weeks. The morphological changes of temporomandibular joints were studied with HE staining. The expression of cartilage matrix compounds (aggrecan and collagen type II), estrogen-related molecules (aromatase, estradiol, ERα and ERβ) and proliferating cell nuclear antigen (PCNA) in mandibular condylar cartilage was detected using immunohistochemistry, ELISA and real-time PCR.
resultsThe genistein treatment significantly reduced the thickness of the posterior and middle regions of mandibular condylar cartilage, and decreased the expression of collagen type II, aggrecan and PCNA. Compared with the control group, the estradiol content and expression levels of the key estradiol-synthesizing enzyme aromatase in the genistein-treatment group were significantly decreased. The genistein treatment significantly increased the expression of ERβ, but decreased the expression of ERα.
conclusionExcess genistein suppresses extracellular matrix synthesis and chondrocytes proliferation, resulting in thinner mandibular condylar cartilage. These effects may be detrimental to the ability of mandibular condylar cartilage to adapt to mechanical loads.
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