ArticleNeuropsychologia2012
Memory monitoring performance and PFC activity are associated with 5-HTTLPR genotype in older adults.
Article in Neuropsychologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- The Protective Role of Neurogenetic Components in Reducing Stress-Related Effects during Spaceflights: Evidence from the Age-Related Positive Memory Approach.Life (Basel, Switzerland) · 2022Review
- Memory Impairment and Plasma BDNF Correlates of theFrontiers in genetics · 2018Article
- Aging and confidence judgments in item recognition.Journal of experimental psychology. Learning, memory, and cognition · 2018Article
- Association between the serotonin transporter gene polymorphism and verbal learning in older adults is moderated by gender.Translational psychiatry · 2017Article
- Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Age is no barrier: predictors of academic success in older learners.NPJ science of learning · 2017Article
- Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory.Neuropsychologia · 2015Article
- Impact of 5-HTTLPR on hippocampal subregional activation in older adults.Translational psychiatry · 2015Article
- Connectivity underlying emotion conflict regulation in older adults with 5-HTTLPR short allele: a preliminary investigation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- A systematic review of type 2 diabetes mellitus and hypertension in imaging studies of cognitive aging: time to establish new norms.Frontiers in aging neuroscience · 2014Review
- Article
- Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Older adults show extensive variability in cognitive performance, including episodic memory. A portion of this variability could potentially be explained by genetic factors. Recent literature shows that the neurotransmitter serotonin plays an important role in memory processes, as enhancements of brain serotonin have led to memory improvement. Here, we have begun to explore genetic contributions to the performance and underlying brain activity associated with source memory monitoring. Using a source recognition memory task during fMRI scanning, this study offers evidence that older adults who carry a short allele (S-car) of the serotonin transporter linked polymorphic region (5-HTTLPR) in the SLC6A4 gene show specific deficits in source memory monitoring relative to older adults who are homozygous for the long allele (LL). These deficits are accompanied by less neural activity in regions of prefrontal cortex that have been shown to support accurate memory monitoring. Moreover, while the older adult LL group's behavioral performance does not differ from younger adults, their brain activation reveals evidence of compensatory activation that likely supports their higher performance level. These results provide preliminary evidence that the long-allele homozygous profile is cognitively beneficial to older adults, particularly for memory functioning.
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Registered trials
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