ArticleBehavioural brain research2012
Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats.
Article in Behavioural brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- A bibliometric analysis of studies on environmental enrichment spanning 1967-2024: patterns and trends over the years.Frontiers in behavioral neuroscience · 2024Article
- Environmental enrichment reverses stress-induced changes in the brain-gut axis to ameliorate chronic visceral and somatic hypersensitivity.Neurobiology of stress · 2024Article
- Recent Studies on the Development of Nicotine Abuse and Behavioral Changes Induced by Chronic Stress Depending on Gender.Brain sciences · 2023Review
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
- Amino acid systems in the interpeduncular nucleus are altered in a sex-dependent manner during nicotine withdrawal.Journal of neuroscience research · 2022Article
- Behavioral effects of environmental enrichment on male and female wistar rats with early life stress experiences.Frontiers in physiology · 2022Article
- Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the central nucleus of the amygdala to inhibit visceral hypersensitivity.Experimental neurology · 2021Article
- The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.Scientific reports · 2021Article
- Impact of Stress on Epilepsy: Focus on Neuroinflammation-A Mini Review.International journal of molecular sciences · 2021Review
- Female rats display greater nicotine withdrawal-induced cellular activation of a central portion of the interpeduncular nucleus versus males: A study of Fos immunoreactivity within provisionally assigned interpeduncular subnuclei.Drug and alcohol dependence · 2021Article
- Estradiol promotes and progesterone reduces anxiety-like behavior produced by nicotine withdrawal in female rats.Psychoneuroendocrinology · 2020Article
- Sex differences in the reward deficit and somatic signs associated with precipitated nicotine withdrawal in rats.Neuropharmacology · 2019Article
- Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal.Neuropharmacology · 2019Article
- Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Current opinion in behavioral sciences · 2018Article
- Nicotine drug discrimination and nicotinic acetylcholine receptors in differentially reared rats.Psychopharmacology · 2018Article
- Hypersensitivity to sertraline in the absence of hippocampal 5-HTEnvironmental epigenetics · 2018Article
- Effects of environmental enrichment on d-amphetamine self-administration following nicotine exposure.Experimental and clinical psychopharmacology · 2017Article
- Behavioral and physiological consequences of enrichment loss in rats.Psychoneuroendocrinology · 2017Article
- Substance use modulates stress reactivity: Behavioral and physiological outcomes.Physiology & behavior · 2016Review
- Stress is a principal factor that promotes tobacco use in females.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
In the present study, we determined the effects of environmental enrichment (EE; Kong Toys and Nestlets) on sexually diergic HPA axis responses to single-dose nicotine (NIC), single-dose NIC following continuous NIC administration for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) in male and female rats. Blood sampling occurred before and after MEC and NIC administrations for the determination of adrenocorticotropic hormone (ACTH) and corticosterone (CORT). Supporting and extending our previous findings, EE appeared to produce anxiolytic effects by reducing hormone responses: Male and female rats housed with EE had lower baseline ACTH and significantly lower HPA axis responses to the mild stress of saline (SAL) injection than did those housed without EE. The sexually diergic responses to single dose NIC, continuous NIC, and MEC-induced NIC withdrawal were reduced by EE in many male and female groups. ACTH responses to continuous NIC and MEC-induced NIC withdrawal were blunted to a greater extent in female EE groups than in male EE groups, suggesting that females are more sensitive to the anxiolytic effects of EE. Because EE lowered stress-responsive hormones of the HPA axis in most groups, EE may be a useful intervention for stress reduction in animal models of NIC addiction. As well, the effectiveness of EE in animal studies of NIC withdrawal may enlighten human studies addressing coping styles and tobacco cessation in men and women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.