ArticleJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2012
Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.
Article in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association between circulating inflammatory biomarkers and functional outcome or perihaematomal oedema after ICH: a systematic review & meta-analysis.Wellcome open research · 2023Pooled it
- Prognostic impact of leukocytosis in intracerebral hemorrhage: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2019Pooled it
- Prediction of Neurological Deterioration After Intracerebral Hemorrhage: The SIGNALS Score.Journal of the American Heart Association · 2022Trial
- Stress hyperglycemia indexes and early neurological deterioration in spontaneous intracerebral hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Dynamic nomogram for predicting early tracheotomy in patients diagnosed with supratentorial deep seated intracranial hemorrhage.Frontiers in neurology · 2025Article
- Association between white blood cells and ultra-early hematoma growth in patients with spontaneous intracerebral hemorrhage.Heliyon · 2024Article
- A high neutrophil-to-platelet ratio is associated with hematoma expansion in patients with spontaneous intracerebral hemorrhage: a retrospective study.BMC neurology · 2023Article
- Predictive value of white blood cell to hemoglobin ratio for 30-day mortality in patients with severe intracerebral hemorrhage.Frontiers in neurology · 2023Article
- Construction of a nomogram to reveal the prognostic benefit of spontaneous intracranial hemorrhage among Chinese adults: a population-based study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study.BMC neurology · 2021Article
- Predicting new silent cerebral infarction after intracerebral hemorrhage using serum white blood cell count.Caspian journal of internal medicine · 2021Article
- High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage.Neuropsychiatric disease and treatment · 2021Article
- Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage.Scientific reports · 2019Article
- Early increase of neutrophil-to-lymphocyte ratio predicts 30-day mortality in patients with spontaneous intracerebral hemorrhage.CNS neuroscience & therapeutics · 2019Article
- Neutrophil to lymphocyte ratio predicts island sign in patients with intracranial hemorrhage.Medicine · 2018Observational
- The diagnostic value of complete blood count parameters in patients with subarachnoid hemorrhage.Turkish journal of emergency medicine · 2017Article
- Inflammatory Biomarkers and Their Value in Predicting Survival and Outcome among Patients with Spontaneous Intracerebral Haemorrhage.The Malaysian journal of medical sciences : MJMS · 2017Article
- Preclinical Studies and Translational Applications of Intracerebral Hemorrhage.BioMed research international · 2017Review
- Article
- Admission Leukocytosis in Intracerebral Hemorrhage: Associated Factors and Prognostic Implications.Neurocritical care · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Intracerebral hemorrhage (ICH) is a devastating and common admitting diagnosis to intensive care units in the USA. Despite advances in critical care, patients with ICH often experience early neurological deterioration (END) in the first 72 hours after admission due to a variety of factors, including hematoma and cerebral edema evolution. The purpose of this study was to determine factors associated with END after ICH. Using the Duke University Hospital Neuroscience Critical Care Unit Database, we retrospectively identified patients with an admitting diagnosis of supratentorial ICH from January to December 2010, verified by CT imaging. END was defined as a decrease in the Glasgow Coma Scale score of ≥3 or death within the first 72 hours after hemorrhage. The chi-squared or t-test analysis was used to compare the groups, as appropriate. Multiple logistical regression modeling was performed to test for associations between likely predictors of END. Of the 89 subjects admitted with supratentorial ICH, we included 83 in the analysis based on complete datasets. Of these, 31 experienced END within 72 hours after onset of symptoms. ICH score, presence of midline shift on imaging, and white blood cell (WBC) count were used in a regression model for predicting END. WBC count demonstrated the greatest association with END. Patients with ICH are prone to END within the first few days after hemorrhage. Elevated WBC count appears predictive of deterioration. These data demonstrate that heightened inflammatory state after ICH may be related to early deterioration after injury.
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Registered trials
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