ArticleBiological psychiatry2012
Gene × gene interaction in shared etiology of autism and specific language impairment.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Language delay aggregates in toddler siblings of children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2018Pooled it
- Language impairment and dyslexia genes influence language skills in children with autism spectrum disorders.Autism research : official journal of the International Society for Autism Research · 2015Pooled it
- Article
- Article
- Structural Variations Contribute to the Genetic Etiology of Autism Spectrum Disorder and Language Impairments.International journal of molecular sciences · 2023Article
- Baseline EEG in the first year of life: Preliminary insights into the development of autism spectrum disorder and language impairments.iScience · 2023Article
- Article
- Comparing Early Pragmatics in Typically Developing Children and Children with Neurodevelopmental Disorders.Journal of autism and developmental disorders · 2022Article
- MicroRNA and MicroRNA-Target Variants Associated with Autism Spectrum Disorder and Related Disorders.Genes · 2022Article
- Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses.Stem cell reports · 2022Article
- Within-task variability on standardized language tests predicts autism spectrum disorder: a pilot study of the Response Dispersion Index.Journal of neurodevelopmental disorders · 2019Article
- Distinct ERP profiles for auditory processing in infants at-risk for autism and language impairment.Scientific reports · 2018Article
- Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds.Behavior genetics · 2017Article
- Statistical Learning in Specific Language Impairment and Autism Spectrum Disorder: A Meta-Analysis.Frontiers in psychology · 2016Article
- Social (pragmatic) communication disorder: a research review of this new DSM-5 diagnostic category.Journal of neurodevelopmental disorders · 2014Review
- Resequencing and association analysis of PTPRA, a possible susceptibility gene for schizophrenia and autism spectrum disorders.PloS one · 2014Article
- A genome scan for loci shared by autism spectrum disorder and language impairment.The American journal of psychiatry · 2014Article
- Human dopamine transporter gene: differential regulation of 18-kb haplotypes.Pharmacogenomics · 2013Article
- Developmental language disorders: challenges and implications of cross-group comparisons.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo examine the relationship between autism spectrum disorders (ASD) and specific language impairment (SLI), family studies typically take a comparative approach where families with one disease are examined for traits of the other disease. In contrast, the present report is the first study with both disorders required to be present in each family to provide a more direct test of the hypothesis of shared genetic etiology.
methodsWe behaviorally assessed 51 families including at least one person with ASD and at least one person with SLI (without ASD). Pedigree members were tested with 22 standardized measures of language and intelligence. Because these extended families include a nonshared environmental contrast, we calculated heritability, not just familiality, for each measure twice: 1) baseline heritability analysis, compared with; 2) heritability estimates after statistically removing ASD subjects from pedigrees.
resultsSignificant increases in heritability on four supra-linguistic measures (including Pragmatic Judgment) and a composite language score but not on any other measures were observed when removing ASD subjects from the analysis, indicating differential genetic effects that are unique to ASD. Nongenetic explanations such as effects of ASD severity or measurement error or low score variability in ASD subjects were systematically ruled out, leaving the hypothesis of nonadditive genetics effects as the potential source of the heritability change caused by ASD.
conclusionsAlthough the data suggest genetic risk factors common to both SLI and ASD, there are effects that seem unique to ASD, possibly caused by nonadditive gene-gene interactions of shared risk loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.