Evidence map›Paper›PMID 22704491›Full record

ReviewChinese journal of cancer2012

Strategies for targeting the DNA damage response for cancer therapeutics.

Dan Zhang, Hai-Bo Wang, Kathryn L Brinkman, Su-Xia Han, Bo Xu

Abstract readEditorialReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chinese journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dan Zhang
Hai-Bo Wang
Kathryn L Brinkman
Su-Xia Han
Bo Xu

Funding

Mechanisms of Mitotic Activation of the ATM kinaseR01CA133093 · NCI · SOUTHERN RESEARCH INSTITUTE · PI XU, BO · 2009 to 2013
$1.4M
A Novel Pathway Involving ATM, PP1 and I-2R01ES016354 · NIEHS · SOUTHERN RESEARCH INSTITUTE · PI MITRA, SANKAR · 2009 to 2012
$1.1M
NCI NIH HHS R01 CA133093NCI NIH HHS R01CA133093NIEHS NIH HHS R01 ES016354NIEHS NIH HHS R01ES016354
6 · The paper itself

Abstract

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

Indexed as

Cell DeathAntineoplastic AgentsDNA DamageDNA RepairDose-Response Relationship, RadiationDrug Resistance, NeoplasmGenomic InstabilityHumansNeoplasmsPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRadiation DosageAntineoplastic AgentsPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) Polymerases

Identifiers

PMID22704491
PMCPMC3777509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.