Trial reportAtherosclerosis2012
Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms.
Trial report in Atherosclerosis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00366990 (Clinical Trial to Reverse Early Arterial Stiffening), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Trial to Reverse Early Arterial Stiffening
Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
- Trial
- Mechanisms underlying the blood pressure-lowering effects of empagliflozin, losartan and their combination in people with type 2 diabetes: A secondary analysis of a randomized crossover trial.Diabetes, obesity & metabolism · 2023Trial
- Regaining body weight after weight reduction further increases pulse wave velocity in obese men with metabolic syndrome.Medicine · 2018Trial
- Weight reduction and aortic stiffness in obese children and adolescents: a 1-year follow-up study.Journal of human hypertension · 2015Trial
- Normobaric hypoxia training causes more weight loss than normoxia training after a 4-week residential camp for obese young adults.Sleep & breathing = Schlaf & Atmung · 2014Trial
- Click "like" to change your behavior: a mixed methods study of college students' exposure to and engagement with Facebook content designed for weight loss.Journal of medical Internet research · 2014Trial
- Impact of weight loss on ankle-brachial index and interartery blood pressures.Obesity (Silver Spring, Md.) · 2014Trial
- The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus.Cardiovascular diabetology · 2014 · on this mapTrial
- Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial.Cardiovascular diabetology · 2012Trial
- Impact of obesity on arterial health among young adults: A bioelectrical impedance study.Bioinformation · 2026Article
- 2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.Acta Cardiologica Sinica · 2024Article
- Nrf2 Signaling Pathway as a Key to Treatment for Diabetic Dyslipidemia and Atherosclerosis.International journal of molecular sciences · 2024Review
- Aortic Stiffness: A Major Risk Factor for Multimorbidity in the Elderly.Journal of clinical medicine · 2023Review
- Clinical Applications Measuring Arterial Stiffness: An Expert Consensus for the Application of Cardio-Ankle Vascular Index.American journal of hypertension · 2022Article
- Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences.Physiology (Bethesda, Md.) · 2022Review
- Metabolomics of Arterial Stiffness.Metabolites · 2022Review
- Pulse pressure and the risk of renal hyperfiltration in young adults: Results from Korea National Health and Nutrition Examination Survey (2010-2019).Frontiers in medicine · 2022Article
- Bariatric Surgery and Hypertension.Journal of clinical medicine · 2021Review
- A New Hope in Type 2 Diabetes Mellitus Management: Sodium-Glucose Cotransporter 2 Inhibitors.Cureus · 2021Review
- Snoring severity is associated with carotid vascular remodeling in young adults with overweight and obesity.Sleep health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveArterial stiffness decreases with weight loss in overweight/obese young adults. We aimed to determine the mechanisms by which this occurs.
methodsWe evaluated carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV) in 344 young adults (23% male, BMI 25-40 kg/m(2)) at baseline, 6, and 12 months in a behavioral weight loss intervention. Linear mixed models were used to evaluate associations between weight loss and arterial stiffness and to examine whether improvements in obesity-related factors explained these associations.
resultsAt 6 months (7% mean weight loss), there was a significant median decrease of 47.5 cm/s in cfPWV (p < 0.0001) and a mean decrease of 11.7 cm/s in baPWV (p = 0.049). At 12 months (6% mean weight loss), only cfPWV remained reduced. In models adjusting for changes in mean arterial pressure and obesity-related factors, changes in BMI (p = 0.01) and common carotid artery diameter (p = 0.003) were positively associated with change in cfPWV. Reductions in heart rate (p < 0.0001) and C-reactive protein (p = 0.02) were associated with reduced baPWV and accounted for the association between weight loss and reduced baPWV.
conclusionsWeight loss is associated with reduced cfPWV independently of changes in established hemodynamic and cardiometabolic risk factors, but its association with reduced baPWV is explained by concurrent reductions in heart rate and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.