ArticleJournal of pediatric surgery2012
Alterations in maternal-fetal cellular trafficking after fetal surgery.
Article in Journal of pediatric surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Fetal surgery is not associated with increased inflammatory placental pathology.Prenatal diagnosis · 2023Article
- Establishment of the fetal-maternal interface: developmental events in human implantation and placentation.Frontiers in cell and developmental biology · 2023Review
- Stage 2: The Vaginal Flora in Women Undergoing Fetal Spina Bifida Repair and Its Potential Association with Preterm Rupture of Membranes and Preterm Birth.Journal of clinical medicine · 2022Article
- Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.Clinical chemistry · 2021Review
- Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.Science translational medicine · 2018Article
- Maternal-fetal cellular trafficking: clinical implications and consequences.Current opinion in pediatrics · 2014Review
- Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice.Chimerism · 2014Article
- Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia.Pediatric research · 2013Article
- Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance.ChimerismArticle
- Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
background/purposeBidirectional trafficking of cells between the mother and the fetus is routine in pregnancy and a component of maternal-fetal tolerance. Changes in fetal-to-maternal cellular trafficking have been reported in prenatal complications, but maternal-to-fetal trafficking has never been studied in the context of fetal intervention. We hypothesized that patients undergoing open fetal surgery would have altered maternal-fetal cellular trafficking.
methodsCellular trafficking was analyzed in patients with myelomeningocele (MMC) who underwent open fetal surgical repair (n = 5), patients with MMC who had routine postnatal repair (n = 6), and healthy control healthy patients (n = 9). As an additional control for the fetal operation, trafficking was also analyzed in patients who were delivered by an ex utero intrapartum treatment procedure (n = 6). Microchimerism in maternal and cord blood was determined using quantitative real-time polymerase chain reaction for nonshared alleles.
resultsMaternal-to-fetal trafficking was significantly increased in patients who underwent open fetal surgery for MMC compared with healthy controls, patients who underwent postnatal MMC repair, and patients who underwent ex utero intrapartum treatment. There were no differences in fetal-to-maternal cell trafficking among groups.
conclusionPatients undergoing open fetal surgery for MMC have elevated levels of maternal microchimerism. These results suggest altered trafficking and/or increased proliferation of maternal cells in fetal blood and may have important implications for preterm labor.
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