ReviewTransfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine2012
CD40 ligand (CD154) involvement in platelet transfusion reactions.
Review in Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Apheresis platelets modulate myeloid dendritic cell immune responses.Scientific reports · 2025Article
- Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients.Transfusion · 2025Article
- Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period.Frontiers in cell and developmental biology · 2025Article
- Comparing transfusion reactions between pre-storage and post-storage leukoreduced apheresis platelets: an analysis using propensity score matching.Annals of hematology · 2024Review
- The platelet storage lesion, what are we working for?Journal of clinical laboratory analysis · 2024Review
- Platelet CD40L Expression Response to Mixing of pRBCs and Washed Platelets but no Causality Association between Platelet ROS Generation and CD40L Expression: An In Vitro Study.Antioxidants (Basel, Switzerland) · 2022Article
- Platelets as Key Factors in Inflammation: Focus on CD40L/CD40.Frontiers in immunology · 2022Review
- Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction.Translational oncology · 2021Review
- Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function.Journal of thrombosis and haemostasis : JTH · 2020Article
- Haemostatic responsiveness and release of biological response modifiers following cryopreservation of platelets treated with amotosalen and ultraviolet A light.Blood transfusion = Trasfusione del sangue · 2020Article
- Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model.Blood transfusion = Trasfusione del sangue · 2019Article
- Evidence of CD40L/CD40 pathway involvement in experimental transfusion-related acute lung injury.Scientific reports · 2019Article
- Platelet Inflammatory Response to Stress.Frontiers in immunology · 2019Review
- Role of Inflammatory Cell Subtypes in Heart Failure.Journal of immunology research · 2019Review
- Towards increasing shelf life and haemostatic potency of stored platelet concentrates.Current opinion in hematology · 2018Review
- Induction of Apoptosis in Cancer Cells of pre-B ALL Patients after Exposure to Platelets, Platelet-Derived Microparticles and Soluble CD40 Ligand.Cell journal · 2018Article
- Reactive Oxygen Species Generated by CD45-Cells Distinct from Leukocyte Population in Platelet Concentrates Is Correlated with the Expression and Release of Platelet Activation Markers during Storage.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Platelet components: is there need or room for quality control assays of storage lesions?Blood transfusion = Trasfusione del sangue · 2018Article
- Leucoreduction of blood components: an effective way to increase blood safety?Blood transfusion = Trasfusione del sangue · 2016Review
- Levels of human platelet-derived soluble CD40 ligand depend on haplotypes of CD40LG-CD40-ITGA2.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Platelet transfusions are commonly used treatments that occasionally lead to adverse reactions. Clinical trials, in vitro and animal studies have been performed to try to understand the causes of such reactions. Multiple studies have shown that the supernatant fraction of platelet concentrates contain prothrombotic and pro-inflammatory mediators. The origin of these mediators was first ascribed to white blood cells contaminating the platelet preparation. However, the accumulation of bioactive mediators after leukoreduction focused attention on platelets themselves during storage. Numerous cytokines, chemokines and prostaglandins are released in stored platelet concentrates. We have focused on a powerful mediator called soluble CD40 ligand (sCD40L, formally known as CD154) as a seminal contributor to adverse reactions. sCD40L can bind and signal the surface receptor, CD40, which is present on various types of human cells including white blood cells, vascular cells and fibroblasts. Downstream results of sCD40L/CD40 signaling include pro-inflammatory cytokine and chemokine production, prothrombotic mediator release, adherence and transmigration of leukocytes to endothelium and other undesirable vascular inflammatory events. Increased plasma levels of sCD40L can be detected in conditions such as myocardial infarction, stroke, unstable angina, high cholesterol, or other cardiovascular conditions. In retrospective studies, correlations were made between increased sCD40L levels of platelet concentrates and adverse transfusion reactions. We hypothesize that transfusion of partially activated, CD40L-expressing platelets along with sCD40L into a recipient with damaged or dysfunctional vascular tissue results in a "double-hit", thus inciting inflammation and vascular damage in the recipient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.